Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

RECENTLY, in vitro studies conducted in our laboratory and others have suggested that apoptosis may have a role in the neuronal cell death associated with Alzheimerʼs disease (AD). To evaluate this hypothesis, the hippocampi and entorhinal cortices of AD, aged control, and surgical biopsy tissue wer...

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Veröffentlicht in:Neuroreport 1994-12, Vol.5 (18), p.2529-2533
Hauptverfasser: Su, Joseph H, Anderson, Alleen J, Cummings, Brian J, Cotman, Carl W
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Sprache:eng
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Zusammenfassung:RECENTLY, in vitro studies conducted in our laboratory and others have suggested that apoptosis may have a role in the neuronal cell death associated with Alzheimerʼs disease (AD). To evaluate this hypothesis, the hippocampi and entorhinal cortices of AD, aged control, and surgical biopsy tissue were examined using the ApopTag system for the detection of DNA fragmentation ana DNA stains to reveal nuclear morphology. Numerous neuronal nuclei displaying distinct morphological characteristics of apoptosis were present within tangle-bearing neurons as well as non-tangle-bearing neurons in AD brain, whereas few or no such nuclei were detected in control brain. Our in vivo results support the hypothesis that apoptosis may be one mechanism leading neuronal cell death in AD.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199412000-00031