Reactivity of Serum Anti-Erythrocyte Membrane Antibody in Babesia gibsoni-Infected Dogs
Reactivity of anti-erythrocyte membrane (RBCm) antibody in sera of B. gibsoni-infected dogs on native RBCm and erythrocyte surface (RBCs) was examined using an enzyme linked immunosorbent assay. Anti-RBCm antibody attached to native RBCm and the surface of erythrocytes (RBC) treated with phenylhydra...
Gespeichert in:
Veröffentlicht in: | Journal of Veterinary Medical Science 1994/10/15, Vol.56(5), pp.997-999 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Reactivity of anti-erythrocyte membrane (RBCm) antibody in sera of B. gibsoni-infected dogs on native RBCm and erythrocyte surface (RBCs) was examined using an enzyme linked immunosorbent assay. Anti-RBCm antibody attached to native RBCm and the surface of erythrocytes (RBC) treated with phenylhydrazine or neuraminidase, but not to the surface of non-treated RBC. Based on these results, anti-cytoskeletal protein antibody in sera of B. gibsoni-infected dogs is considered to attach to native RBCm, and furthermore free radical-induced oxidative stress imposed on RBC and sialic acid removal from glycoproteins of RBC are considered necessary for anti-transmembrane protein antibody in sera of B. gibsoni-infected dogs to be bound to RBCs. These are important to elucidating the mechanism of the marked increase in RBCs-bound IgG value and anemia in B. gibsoni infection. |
---|---|
ISSN: | 0916-7250 1347-7439 |
DOI: | 10.1292/jvms.56.997 |