Isolation of a human cerebral imidazoline-specific binding protein

The first isolation of a human brain specific imidazoline binding protein is described. This protein was obtained using affinity chromatography and was revealed with the aid of an anti-idiotypic antibody specific for imidazoline binding sites. The protein (43 kDa) differs from other imidazoline bind...

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Veröffentlicht in:	European journal of pharmacology 1994-11, Vol.265 (1), p.R1-R2
Hauptverfasser:	Greney, Hugues, Bennai, Fatima, Molines, Annick, Belcourt, Alain, Dontenwill, Monique, Bousquet, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Anti-Idiotypic - metabolism Antibody Specificity Antihypertensive agents Biological and medical sciences Brain, human Cardiovascular system Carrier Proteins - drug effects Carrier Proteins - isolation & purification Carrier Proteins - metabolism Cerebral Cortex - metabolism Chromatography, Affinity Clonidine Clonidine - pharmacology Electrophoresis, Polyacrylamide Gel Humans Imidazoles - metabolism Imidazoline Imidazoline Receptors Immunoblotting Medical sciences Molecular Weight Pharmacology. Drug treatments Receptors, Drug - metabolism
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Zusammenfassung:	The first isolation of a human brain specific imidazoline binding protein is described. This protein was obtained using affinity chromatography and was revealed with the aid of an anti-idiotypic antibody specific for imidazoline binding sites. The protein (43 kDa) differs from other imidazoline binding proteins previously isolated from peripheral tissues, in particular by being also sensitive to clonidine.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(94)90234-8