Cytoplasmic c-erbB-2 protein expression correlates with survival in Dukes' B colorectal carcinoma

The prognostic significance of c‐erbB‐2 expression was studied in paraffin wax embedded colorectal cancer tissue using a monoclonal antibody. One hundred and sixty‐four patients with Dukes' B disease were studied. Membranous staining was not detected in any case. Cytoplasmic c‐erbB‐2 staining w...

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Veröffentlicht in:Histopathology 1994-11, Vol.25 (5), p.455-461
Hauptverfasser: KAY, E.W., MULCAHY, H., WALSH, C. BARRY, LEADER, M., O'DONOGHUE, D.
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Sprache:eng
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Zusammenfassung:The prognostic significance of c‐erbB‐2 expression was studied in paraffin wax embedded colorectal cancer tissue using a monoclonal antibody. One hundred and sixty‐four patients with Dukes' B disease were studied. Membranous staining was not detected in any case. Cytoplasmic c‐erbB‐2 staining was seen in 55 cancers (33.5%). Cytoplasmic taining was unrelated to patient age (P= 0.31), sex (P= 0.69), tumour site (P= 0.69), size (P= 0.57), histological grade (P= 0.42) or ploidy status (P= 0.21) but was found more frequently in obstructing cancers (P= 0.03). Mean follow up of the patient population was 6.3 years. Five‐year‐survival estimated by the Kaplan‐Meier life‐table method was 47% for those with cytoplasmic c‐erbB‐2 staining and 77% for those without (log rank analysis; P? 0.0001). Stepwise regression analysis identified c‐erbB‐2 staining (relative risk, 2.51; P= 0.0005) and bowel obstruction (relative risk, 1.99; P= 0.015) as independent predictors of survival. It is suggested that cytoplasmic c‐erbB‐2 expression may provide a useful marker of tumour behaviour in Dukes' B colorectal cancer.
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.1994.tb00007.x