High risk genotypes for celiac disease

High risk genotypes for celiac disease

It is known that celiac disease is strongly associated with an HLA class II component and that most patients carry the dimer DQA1*0501, DQB1*0201. We show in this study that the risk for a carrier of this heterodimer is independent from the number of possible heterodimers, from whether DQA1*0501 and...

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Veröffentlicht in:Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie Série III, Sciences de la vie, 1994-10, Vol.317 (10), p.931-936
Hauptverfasser: CLERGET-DARPOUX, F, BOUGUERRA, F, KASTALLY, R, SEMANA, G, BABRON, M.-C, DEBBABI, A, BENNACEUR, B, ELIAOU, J.-F
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Alleles
Biological and medical sciences
Celiac Disease - epidemiology
Celiac Disease - genetics
Child
Child, Preschool
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genotype
HLA-DQ Antigens - genetics
Humans
Infant
Male
Medical sciences
Other diseases. Semiology
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Zusammenfassung:It is known that celiac disease is strongly associated with an HLA class II component and that most patients carry the dimer DQA1*0501, DQB1*0201. We show in this study that the risk for a carrier of this heterodimer is independent from the number of possible heterodimers, from whether DQA1*0501 and DQB1*0201 are in cis or trans position and from the number of DQA1*0501 (one or two) but strongly depends on the number of DQB1*0201. In the Tunisian population we studied, the risk of developing celiac disease is estimated to be 6.8 times greater for those having a double dose of DQB1*0201 than for other dimer carriers. We replicated this result in published data of four other populations (Italy, Czekoslovakia, United Kingdom, Norway).
ISSN:0764-4469