Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents

A series of fused pyrazole derivatives of cyclolignans have been prepared through simple chemical routes and evaluated for their cytotoxic activities in culture cells of P-388 murine leukemia, A-549 lung carcinoma and HT-29 colon carcinoma. Despite the lack of the lactone moiety in their structures,...

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Veröffentlicht in:Bioorganic & medicinal chemistry 1995-09, Vol.3 (9), p.1203-1210
Hauptverfasser: Gordaliza, Marina, Miguel del Corral, JoséM., Angeles Castro, M., Luisa López-Vázquez, M., San Feliciano, Arturo, Dolores García-Grávalos, M., Carpy, Alain
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Sprache:eng
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