Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents

A series of fused pyrazole derivatives of cyclolignans have been prepared through simple chemical routes and evaluated for their cytotoxic activities in culture cells of P-388 murine leukemia, A-549 lung carcinoma and HT-29 colon carcinoma. Despite the lack of the lactone moiety in their structures, they show IC 50 values at μM levels. Fused pyrazoline derivatives of cyclolignans have been prepared and evaluated for their cytotoxic activity in P-388, A-549 and HT-29 culture cells. They show IC 50 Values at μM levels.