Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization

Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization

Seven classes of Streptomyces clavuligerus mutants defective in clavulanic acid (CLA) biosynthesis have been identified and used to clone the chromosomal DNA encoding eight CLA biosynthetic genes. The complete sequences of three and the partial sequences of two of these biosynthetic genes are report...

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Veröffentlicht in:Gene 1995-12, Vol.166 (1), p.49-55
Hauptverfasser: Hodgson, John E, Fosberry, Andrew P, Rawlinson, Nichola S, Ross, Hamish N.M, Neal, Robert J, Arnell, Janice C, Earl, Alison J, Lawlor, Elizabeth J
Format: Artikel
Sprache:eng
Schlagworte:
Acetyltransferase
Acetyltransferases - genetics
amidinohydrolase
Amino Acid Sequence
Anti-Bacterial Agents - biosynthesis
antibiotic
arginine
Base Sequence
Clavulanic Acid
Clavulanic Acids - biosynthesis
Cloning, Molecular
DNA, Bacterial - genetics
Genes, Bacterial
Genetic Complementation Test
Molecular Sequence Data
phosphate
Promoter Regions, Genetic
Restriction Mapping
Streptococcus - genetics
transport
Ureohydrolases - genetics
β-lactam
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Zusammenfassung:Seven classes of Streptomyces clavuligerus mutants defective in clavulanic acid (CLA) biosynthesis have been identified and used to clone the chromosomal DNA encoding eight CLA biosynthetic genes. The complete sequences of three and the partial sequences of two of these biosynthetic genes are reported, together with their known or predicted functions.
ISSN:0378-1119
1879-0038
DOI:10.1016/0378-1119(95)00560-9