Effect of rufloxacin upon non-specific immune defences: in-vitro, ex-vivo and in-vivo results
This study investigated in-vitro, ex-vivo and in-vivo the immunomodulatory effects of rufloxacin. 0–5 MIC of rufloxacin significantly enhanced human macrophage phagocytosis and increased intracellular killing of Klebsiella pneumoniae in vitro. Pre-incubation of K. pneumoniae with rufloxacin made the...
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Veröffentlicht in: | Journal of antimicrobial chemotherapy 1994-10, Vol.34 (4), p.545-553 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | This study investigated in-vitro, ex-vivo and in-vivo the immunomodulatory effects of rufloxacin. 0–5 MIC of rufloxacin significantly enhanced human macrophage phagocytosis and increased intracellular killing of Klebsiella pneumoniae in vitro. Pre-incubation of K. pneumoniae with rufloxacin made the bacteria more susceptible to both phagocytosis and intracellular killing by human macrophages than control organisms. Following pre-exposure of macrophages to 0.5 MIC of rufloxacin, there was a significant increase in the intracellular killing of K. pneumoniae compared with the controls, indicating the ability of rufloxacin to cross biological membranes and to remain active within phagocytes. Ex-vivo experiments show that iv administration of rufloxacin in mice lead to an increase in both phagocytic and microbicidal intracellular activity by phagocytes. In-vivo models of experimental infections showed that prophylactic administration of rufloxacin increased the survival of mice after challenge with Candida albicans. |
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ISSN: | 0305-7453 1460-2091 |
DOI: | 10.1093/jac/34.4.545 |