Comparative in vitro activity of furopenem against aerobic bacteria isolated from pediatric patients
The in vitro activity of the oral penem furopenem (WY-49605, 545555, SUN5555, and ALP201) was tested against clinical bacteria isolated from pediatric patients. Furopenem was compared with clarithromycin, cefpodoxime, amoxicillin, amoxicillin-clavulanate, cefaclor, cefixime, and cefuroxime. Furopene...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 1995-07, Vol.22 (3), p.301-306 |
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| creator | Mortensen, Joel E. Egleton, Jean H. |
| description | The in vitro activity of the oral penem furopenem (WY-49605, 545555, SUN5555, and ALP201) was tested against clinical bacteria isolated from pediatric patients. Furopenem was compared with clarithromycin, cefpodoxime, amoxicillin, amoxicillin-clavulanate, cefaclor, cefixime, and cefuroxime. Furopenem demonstrated consistent activity against
Escherichia coli [minimum inhibitory concentration (MIC
90) = 1.0 μg/ml)]
Klebsiella pneumoniae (MIC
90 = 2.0 μg/ml),
Salmonella enteriditis and
Shigella spp. (MIC
90 = 1.0 μg/ml), and β-lactamase-positive or -negative
Haemophilus influenzae (MIC
90 = 1.0 μg/ml) and
Moraella catarrhalis (MIC
90 = 1.0 μg/ml). Furopenem was also active against a number of the Gram-positive organisms tested including methicillin-susceptible
Staphylococcus aureus and penicillin-susceptible
Streptococcus pneumoniae. These results suggest a potential application for this agent in the treatment of children as outpatients. |
| doi_str_mv | 10.1016/0732-8893(95)00098-U |
| format | Article |
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Escherichia coli [minimum inhibitory concentration (MIC
90) = 1.0 μg/ml)]
Klebsiella pneumoniae (MIC
90 = 2.0 μg/ml),
Salmonella enteriditis and
Shigella spp. (MIC
90 = 1.0 μg/ml), and β-lactamase-positive or -negative
Haemophilus influenzae (MIC
90 = 1.0 μg/ml) and
Moraella catarrhalis (MIC
90 = 1.0 μg/ml). Furopenem was also active against a number of the Gram-positive organisms tested including methicillin-susceptible
Staphylococcus aureus and penicillin-susceptible
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Escherichia coli [minimum inhibitory concentration (MIC
90) = 1.0 μg/ml)]
Klebsiella pneumoniae (MIC
90 = 2.0 μg/ml),
Salmonella enteriditis and
Shigella spp. (MIC
90 = 1.0 μg/ml), and β-lactamase-positive or -negative
Haemophilus influenzae (MIC
90 = 1.0 μg/ml) and
Moraella catarrhalis (MIC
90 = 1.0 μg/ml). Furopenem was also active against a number of the Gram-positive organisms tested including methicillin-susceptible
Staphylococcus aureus and penicillin-susceptible
Streptococcus pneumoniae. These results suggest a potential application for this agent in the treatment of children as outpatients.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteria, Aerobic - drug effects</subject><subject>Bacteria, Aerobic - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Carbapenems - pharmacology</subject><subject>Cephalosporins - pharmacology</subject><subject>Child, Preschool</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Penicillins - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGKFDEQhoMo6-zqGyjkIKKHXiud7iR9EWRw3YUFL845JOmKRLo7bZIZ2LffjDPM0VNR1Fc_VR8h7xjcMmDiC0jeNkoN_NPQfwaAQTW7F2TDlBwaAAkvyeaCvCbXOf8BYO3QwRW5Ur3ou5ZtyLiN82qSKeGANCz0EEqK1Ljah_JEo6d-n-KKC87U_DZhyYUaTNEGR23FMAVDQ46TKThSn-JMVxyDKakCa43FpeQ35JU3U8a353pDdnfff23vm8efPx623x4bx5UozeAtF14aZJ0dBIJQUkkQsvcjA-C-vth3yJkUVtlWGOeF6py0vBWyHa3lN-TjKXdN8e8ec9FzyA6nySwY91lLWX10SlawO4EuxZwTer2mMJv0pBnoo1x9NKeP5vTQ639y9a6uvT_n7-2M42XpbLPOP5znJjsz-WQWF_IF40J0rIWKfT1hWF0cAiadXfXkqreErugxhv_f8QzcXJbw</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Mortensen, Joel E.</creator><creator>Egleton, Jean H.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950701</creationdate><title>Comparative in vitro activity of furopenem against aerobic bacteria isolated from pediatric patients</title><author>Mortensen, Joel E. ; Egleton, Jean H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-9fb36f7ae14b96e0687870675fd1003f00954e3176b8b26acf684c7b32672dbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacteria, Aerobic - drug effects</topic><topic>Bacteria, Aerobic - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Carbapenems - pharmacology</topic><topic>Cephalosporins - pharmacology</topic><topic>Child, Preschool</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Penicillins - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mortensen, Joel E.</creatorcontrib><creatorcontrib>Egleton, Jean H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mortensen, Joel E.</au><au>Egleton, Jean H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative in vitro activity of furopenem against aerobic bacteria isolated from pediatric patients</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>22</volume><issue>3</issue><spage>301</spage><epage>306</epage><pages>301-306</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><coden>DMIDDZ</coden><abstract>The in vitro activity of the oral penem furopenem (WY-49605, 545555, SUN5555, and ALP201) was tested against clinical bacteria isolated from pediatric patients. Furopenem was compared with clarithromycin, cefpodoxime, amoxicillin, amoxicillin-clavulanate, cefaclor, cefixime, and cefuroxime. Furopenem demonstrated consistent activity against
Escherichia coli [minimum inhibitory concentration (MIC
90) = 1.0 μg/ml)]
Klebsiella pneumoniae (MIC
90 = 2.0 μg/ml),
Salmonella enteriditis and
Shigella spp. (MIC
90 = 1.0 μg/ml), and β-lactamase-positive or -negative
Haemophilus influenzae (MIC
90 = 1.0 μg/ml) and
Moraella catarrhalis (MIC
90 = 1.0 μg/ml). Furopenem was also active against a number of the Gram-positive organisms tested including methicillin-susceptible
Staphylococcus aureus and penicillin-susceptible
Streptococcus pneumoniae. These results suggest a potential application for this agent in the treatment of children as outpatients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8565421</pmid><doi>10.1016/0732-8893(95)00098-U</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0732-8893 |
| ispartof | Diagnostic microbiology and infectious disease, 1995-07, Vol.22 (3), p.301-306 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria, Aerobic - drug effects Bacteria, Aerobic - isolation & purification Biological and medical sciences Carbapenems - pharmacology Cephalosporins - pharmacology Child, Preschool Humans Medical sciences Microbial Sensitivity Tests Penicillins - pharmacology Pharmacology. Drug treatments |
| title | Comparative in vitro activity of furopenem against aerobic bacteria isolated from pediatric patients |
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