Comparative in vitro activity of furopenem against aerobic bacteria isolated from pediatric patients
The in vitro activity of the oral penem furopenem (WY-49605, 545555, SUN5555, and ALP201) was tested against clinical bacteria isolated from pediatric patients. Furopenem was compared with clarithromycin, cefpodoxime, amoxicillin, amoxicillin-clavulanate, cefaclor, cefixime, and cefuroxime. Furopene...
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Veröffentlicht in: | Diagnostic microbiology and infectious disease 1995-07, Vol.22 (3), p.301-306 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The in vitro activity of the oral penem furopenem (WY-49605, 545555, SUN5555, and ALP201) was tested against clinical bacteria isolated from pediatric patients. Furopenem was compared with clarithromycin, cefpodoxime, amoxicillin, amoxicillin-clavulanate, cefaclor, cefixime, and cefuroxime. Furopenem demonstrated consistent activity against
Escherichia coli [minimum inhibitory concentration (MIC
90) = 1.0 μg/ml)]
Klebsiella pneumoniae (MIC
90 = 2.0 μg/ml),
Salmonella enteriditis and
Shigella spp. (MIC
90 = 1.0 μg/ml), and β-lactamase-positive or -negative
Haemophilus influenzae (MIC
90 = 1.0 μg/ml) and
Moraella catarrhalis (MIC
90 = 1.0 μg/ml). Furopenem was also active against a number of the Gram-positive organisms tested including methicillin-susceptible
Staphylococcus aureus and penicillin-susceptible
Streptococcus pneumoniae. These results suggest a potential application for this agent in the treatment of children as outpatients. |
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ISSN: | 0732-8893 1879-0070 |
DOI: | 10.1016/0732-8893(95)00098-U |