Effects of tachykinins on the splanchnic circulation: A comparison of the dog and rat

Responses to the administration of graduated doses of tachykinins were examined in various vascular beds of the dog. Among the tachykinins, all vascular beds studied demonstrated that the greatest vasodilation responses was produced by substance P. However, each tachykinin demonstrated a specific pa...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1994, Vol.15 (7), p.1189-1194
Hauptverfasser:	Prokopiw, I., McDonald, T.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood flow Celiac artery Dog Dogs Female Hemodynamics - drug effects Male Mesenteric Artery, Superior - drug effects Neurokinin A Neurokinin A - pharmacology Neurokinin B Neurokinin B - pharmacology Rat Rats Rats, Wistar Species Specificity Splanchnic circulation Splanchnic Circulation - drug effects Splanchnic Circulation - physiology Substance P Substance P - pharmacology Superior mesenteric artery Tachykinins Tachykinins - administration & dosage Tachykinins - pharmacology Vascular Resistance - drug effects Vasodilation - drug effects
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Zusammenfassung:	Responses to the administration of graduated doses of tachykinins were examined in various vascular beds of the dog. Among the tachykinins, all vascular beds studied demonstrated that the greatest vasodilation responses was produced by substance P. However, each tachykinin demonstrated a specific pattern of response. With substance P the greatest sensitivity was seen in the superior mesenteric artery (SMA), with neurokinin B in the celiac axis, and with neurokinin B a prolonged vasodilatation response of the SMA compared to the other two vessels was seen. The response to substance P in the SMA of the rat was considerably less than that of the dog.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/0196-9781(94)90141-4