Improvement in Circulatory and Oxygenation Status by Perflubron Emulsion (Oxygent™ HT) in a Canine Model of Surgical Hemodilution
To examine the effect of a low dose of Oxygent™ HT on hemodynamics and oxygen transport variables in a canine mode) of profound surgical hemodilution, two groups of adult anesthetized splenectomized beagles were hemodiluted with Ringer's solution to Hb 7 g/dL. The treated group received 1 mL/kg...
Gespeichert in:
Veröffentlicht in: | Artificial cells, blood substitutes, and immobilization biotechnology blood substitutes, and immobilization biotechnology, 1994, Vol.22 (4), p.965-977 |
---|---|
Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | To examine the effect of a low dose of Oxygent™ HT on hemodynamics and oxygen transport variables in a canine mode) of profound surgical hemodilution, two groups of adult anesthetized splenectomized beagles were hemodiluted with Ringer's solution to Hb 7 g/dL. The treated group received 1 mL/kg Oxygent™ HT (90% w/v perflubron emulsion perfluorooctyl bromide], Alliance Pharmaceutical Corp.) and both groups (7 controls and 10 treated) were further hemodiluted using 6% hydroxyethyl starch until cardiorespiratory decompensation occurred. Pulmonary artery catheterization data and oxygen transport variables were recorded at Hb decrements of 1 g/dL breathing room air. There was no difference among groups during initial hemodilution. However, in the Oxygent™ HT group there was a statistically significant improvement in mean arterial pressure, CVP, cardiac output, PvO2, SvO2, D02 and pulmonary venous admixture shunt during profound hemodilution to Hb levels of 6, 5, and 4 g/dL. A low dose of Oxygent™ HT offered benefit in improving hemodynamics and oxygen transport parameters even under air breathing conditions in a model of surgical hemodilution. This effect was most apparent at lower levels of Hb. |
---|---|
ISSN: | 1073-1199 1532-4184 |
DOI: | 10.3109/10731199409138795 |