Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice
We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1995-11, Vol.59 (11), p.2191-2192 |
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| container_end_page | 2192 |
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| container_issue | 11 |
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| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 59 |
| creator | NAKAGAWA, Y ASAI, H KITOH, J MORI, H NAKANO, K |
| description | We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice. |
| doi_str_mv | 10.1271/bbb.59.2191 |
| format | Article |
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We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.59.2191</identifier><identifier>PMID: 8541664</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience Biotechnology and Agrochemistry</publisher><subject>3-Hydroxyanthranilate 3,4-Dioxygenase ; Animals ; Biological and medical sciences ; Biotechnology ; Brain - enzymology ; Brain - metabolism ; Dioxygenases ; Epilepsy - enzymology ; Epilepsy - genetics ; Genetic Predisposition to Disease ; Medical sciences ; Mice ; Molecular Sequence Data ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Oxygenases - genetics ; Quinolinic Acid - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism</subject><ispartof>Bioscience, biotechnology, and biochemistry, 1995-11, Vol.59 (11), p.2191-2192</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2970077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8541664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAKAGAWA, Y</creatorcontrib><creatorcontrib>ASAI, H</creatorcontrib><creatorcontrib>KITOH, J</creatorcontrib><creatorcontrib>MORI, H</creatorcontrib><creatorcontrib>NAKANO, K</creatorcontrib><title>Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). 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| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 1995-11, Vol.59 (11), p.2191-2192 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77729574 |
| source | J-STAGE Free; MEDLINE; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 3-Hydroxyanthranilate 3,4-Dioxygenase Animals Biological and medical sciences Biotechnology Brain - enzymology Brain - metabolism Dioxygenases Epilepsy - enzymology Epilepsy - genetics Genetic Predisposition to Disease Medical sciences Mice Molecular Sequence Data Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Oxygenases - genetics Quinolinic Acid - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism |
| title | Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice |
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