Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice

We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1995-11, Vol.59 (11), p.2191-2192
Hauptverfasser:	NAKAGAWA, Y, ASAI, H, KITOH, J, MORI, H, NAKANO, K
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxyanthranilate 3,4-Dioxygenase Animals Biological and medical sciences Biotechnology Brain - enzymology Brain - metabolism Dioxygenases Epilepsy - enzymology Epilepsy - genetics Genetic Predisposition to Disease Medical sciences Mice Molecular Sequence Data Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Oxygenases - genetics Quinolinic Acid - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism
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Zusammenfassung:	We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.59.2191