Synthesis of acylphosphonyl analogues of phosphatidyl- myo-inositol as inhibitors of phosphatidylinositol-specific phospholipase C
The synthesis and inhibitory activity of two acylphosphonates of myo-inositol on phosphatidylinositol-specific phospholipase C (PI-PLC) is described. The compounds were characterized by thin-layer chromatography, column chromatography, NMR spectroscopy, Fourier transform infrared spectroscopy, and m...
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| Veröffentlicht in: | Carbohydrate research 1994-12, Vol.265 (1), p.139-143 |
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| container_end_page | 143 |
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| container_issue | 1 |
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| container_title | Carbohydrate research |
| container_volume | 265 |
| creator | Alisi, Maria A. Brufani, Mario Filocamo, Luigi Cellai, Luciano Iannelli, M.Adelaide Cesta, Maria C. Lappa, Sperandina |
| description | The synthesis and inhibitory activity of two acylphosphonates of myo-inositol on phosphatidylinositol-specific phospholipase C (PI-PLC) is described. The compounds were characterized by thin-layer chromatography, column chromatography, NMR spectroscopy, Fourier transform infrared spectroscopy, and melting point determinations. |
| doi_str_mv | 10.1016/0008-6215(94)00213-4 |
| format | Article |
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The compounds were characterized by thin-layer chromatography, column chromatography, NMR spectroscopy, Fourier transform infrared spectroscopy, and melting point determinations.</description><identifier>ISSN: 0008-6215</identifier><identifier>EISSN: 1873-426X</identifier><identifier>DOI: 10.1016/0008-6215(94)00213-4</identifier><identifier>PMID: 7834650</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Acylphosphonyl analogues ; Phosphatidyl- myo-inositol ; Phosphatidylinositol Diacylglycerol-Lyase ; Phosphatidylinositols - chemical synthesis ; Phosphodiesterase Inhibitors - chemical synthesis ; Phosphoinositide Phospholipase C ; Phospholipase ; Phosphoric Diester Hydrolases - chemistry ; Synthesis</subject><ispartof>Carbohydrate research, 1994-12, Vol.265 (1), p.139-143</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-17513767a1ce0709b1a5c43baa903ab6912953e0b6533459a95ac55fc547596f3</citedby><cites>FETCH-LOGICAL-c388t-17513767a1ce0709b1a5c43baa903ab6912953e0b6533459a95ac55fc547596f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0008621594002134$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7834650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alisi, Maria A.</creatorcontrib><creatorcontrib>Brufani, Mario</creatorcontrib><creatorcontrib>Filocamo, Luigi</creatorcontrib><creatorcontrib>Cellai, Luciano</creatorcontrib><creatorcontrib>Iannelli, M.Adelaide</creatorcontrib><creatorcontrib>Cesta, Maria C.</creatorcontrib><creatorcontrib>Lappa, Sperandina</creatorcontrib><title>Synthesis of acylphosphonyl analogues of phosphatidyl- myo-inositol as inhibitors of phosphatidylinositol-specific phospholipase C</title><title>Carbohydrate research</title><addtitle>Carbohydr Res</addtitle><description>The synthesis and inhibitory activity of two acylphosphonates of myo-inositol on phosphatidylinositol-specific phospholipase C (PI-PLC) is described. The compounds were characterized by thin-layer chromatography, column chromatography, NMR spectroscopy, Fourier transform infrared spectroscopy, and melting point determinations.</description><subject>Acylphosphonyl analogues</subject><subject>Phosphatidyl- myo-inositol</subject><subject>Phosphatidylinositol Diacylglycerol-Lyase</subject><subject>Phosphatidylinositols - chemical synthesis</subject><subject>Phosphodiesterase Inhibitors - chemical synthesis</subject><subject>Phosphoinositide Phospholipase C</subject><subject>Phospholipase</subject><subject>Phosphoric Diester Hydrolases - chemistry</subject><subject>Synthesis</subject><issn>0008-6215</issn><issn>1873-426X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LxDAQhoMo67r6DxR6Ej1Uk-aruQiy-AULHlTwFtI0dSNtU5uu0Ku_3Oy27kXQQ0hm3mdmmLwAHCN4gSBilxDCNGYJomeCnEOYIByTHTBFKQ-PhL3ugukW2QcH3r-HEDLOJmDCU0wYhVPw9dTX3dJ46yNXREr3ZbN0Ppy6LyNVq9K9rcxGG_Kqs3lfxlHVu9jWztvOBc5Htl7aLATtL_aHin1jtC2sHlVX2kZ5E80PwV6hSm-OxnsGXm5vnuf38eLx7mF-vYg1TtMuRpwizBlXSBvIociQoprgTCkBscqYQImg2MCMUYwJFUpQpSktNCWcClbgGTgd-jat-whLdbKyXpuyVLVxKy855wkVRPwLIiZwIggNIBlA3TrvW1PIprWVanuJoFx7JNcGyLUBUhC58UiSUHYy9l9llcm3RaMpQb8adBN-49OaVnptTa1NblujO5k7-_eAb09iozY</recordid><startdate>19941202</startdate><enddate>19941202</enddate><creator>Alisi, Maria A.</creator><creator>Brufani, Mario</creator><creator>Filocamo, Luigi</creator><creator>Cellai, Luciano</creator><creator>Iannelli, M.Adelaide</creator><creator>Cesta, Maria C.</creator><creator>Lappa, Sperandina</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19941202</creationdate><title>Synthesis of acylphosphonyl analogues of phosphatidyl- myo-inositol as inhibitors of phosphatidylinositol-specific phospholipase C</title><author>Alisi, Maria A. ; Brufani, Mario ; Filocamo, Luigi ; Cellai, Luciano ; Iannelli, M.Adelaide ; Cesta, Maria C. ; Lappa, Sperandina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-17513767a1ce0709b1a5c43baa903ab6912953e0b6533459a95ac55fc547596f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acylphosphonyl analogues</topic><topic>Phosphatidyl- myo-inositol</topic><topic>Phosphatidylinositol Diacylglycerol-Lyase</topic><topic>Phosphatidylinositols - chemical synthesis</topic><topic>Phosphodiesterase Inhibitors - chemical synthesis</topic><topic>Phosphoinositide Phospholipase C</topic><topic>Phospholipase</topic><topic>Phosphoric Diester Hydrolases - chemistry</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alisi, Maria A.</creatorcontrib><creatorcontrib>Brufani, Mario</creatorcontrib><creatorcontrib>Filocamo, Luigi</creatorcontrib><creatorcontrib>Cellai, Luciano</creatorcontrib><creatorcontrib>Iannelli, M.Adelaide</creatorcontrib><creatorcontrib>Cesta, Maria C.</creatorcontrib><creatorcontrib>Lappa, Sperandina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alisi, Maria A.</au><au>Brufani, Mario</au><au>Filocamo, Luigi</au><au>Cellai, Luciano</au><au>Iannelli, M.Adelaide</au><au>Cesta, Maria C.</au><au>Lappa, Sperandina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of acylphosphonyl analogues of phosphatidyl- myo-inositol as inhibitors of phosphatidylinositol-specific phospholipase C</atitle><jtitle>Carbohydrate research</jtitle><addtitle>Carbohydr Res</addtitle><date>1994-12-02</date><risdate>1994</risdate><volume>265</volume><issue>1</issue><spage>139</spage><epage>143</epage><pages>139-143</pages><issn>0008-6215</issn><eissn>1873-426X</eissn><abstract>The synthesis and inhibitory activity of two acylphosphonates of myo-inositol on phosphatidylinositol-specific phospholipase C (PI-PLC) is described. The compounds were characterized by thin-layer chromatography, column chromatography, NMR spectroscopy, Fourier transform infrared spectroscopy, and melting point determinations.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>7834650</pmid><doi>10.1016/0008-6215(94)00213-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-6215 |
| ispartof | Carbohydrate research, 1994-12, Vol.265 (1), p.139-143 |
| issn | 0008-6215 1873-426X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77725949 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acylphosphonyl analogues Phosphatidyl- myo-inositol Phosphatidylinositol Diacylglycerol-Lyase Phosphatidylinositols - chemical synthesis Phosphodiesterase Inhibitors - chemical synthesis Phosphoinositide Phospholipase C Phospholipase Phosphoric Diester Hydrolases - chemistry Synthesis |
| title | Synthesis of acylphosphonyl analogues of phosphatidyl- myo-inositol as inhibitors of phosphatidylinositol-specific phospholipase C |
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