Synthesis of acylphosphonyl analogues of phosphatidyl- myo-inositol as inhibitors of phosphatidylinositol-specific phospholipase C

The synthesis and inhibitory activity of two acylphosphonates of myo-inositol on phosphatidylinositol-specific phospholipase C (PI-PLC) is described. The compounds were characterized by thin-layer chromatography, column chromatography, NMR spectroscopy, Fourier transform infrared spectroscopy, and m...

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Veröffentlicht in:	Carbohydrate research 1994-12, Vol.265 (1), p.139-143
Hauptverfasser:	Alisi, Maria A., Brufani, Mario, Filocamo, Luigi, Cellai, Luciano, Iannelli, M.Adelaide, Cesta, Maria C., Lappa, Sperandina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylphosphonyl analogues Phosphatidyl- myo-inositol Phosphatidylinositol Diacylglycerol-Lyase Phosphatidylinositols - chemical synthesis Phosphodiesterase Inhibitors - chemical synthesis Phosphoinositide Phospholipase C Phospholipase Phosphoric Diester Hydrolases - chemistry Synthesis
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Beschreibung
Zusammenfassung:	The synthesis and inhibitory activity of two acylphosphonates of myo-inositol on phosphatidylinositol-specific phospholipase C (PI-PLC) is described. The compounds were characterized by thin-layer chromatography, column chromatography, NMR spectroscopy, Fourier transform infrared spectroscopy, and melting point determinations.
ISSN:	0008-6215 1873-426X
DOI:	10.1016/0008-6215(94)00213-4