Polyclonal Antiidiotypic Antibodies Mimicking gp120 of HIV-1
Rabbit antiidiotypic antibodies (Ab2) were produced against anti-HIV-1 antibody 0.5β (Ab1), which binds to gp120 of HIV-1 and shows virus-neutralizing activity. The Ab2 bound specifically to the Ab1 and their binding to Ab2 was inhibited by a recombinant fragment of gp120 (PB1) or a peptide (residue...
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| Veröffentlicht in: | Viral immunology 1994, Vol.7 (2), p.61-69 |
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| container_title | Viral immunology |
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| creator | SPERLAGH, M HOXIE, J MARUYAMA, H STEFANO, K GONZALES-SCARANO, F PREWETT, M SHAONONG LIANG MATSUSHITA, S HERLYN, D |
| description | Rabbit antiidiotypic antibodies (Ab2) were produced against anti-HIV-1 antibody 0.5β (Ab1), which binds to gp120 of HIV-1 and shows virus-neutralizing activity. The Ab2 bound specifically to the Ab1 and their binding to Ab2 was inhibited by a recombinant fragment of gp120 (PB1) or a peptide (residues 301–324 of gp120), both expressing the Ab1-defined epitope. The Ab2 induced in rats antiantiidiotypic antibodies (Ab3) that were Ab1-like in their binding reactivities to PB1, native gp120 or peptide and shared idiotopes with the Ab1. However, the Ab2 did not induce virus-neutralizing Ab3, probably a reflection of the low avidity of the Ab3 as compared to the Ab1. |
| doi_str_mv | 10.1089/vim.1994.7.61 |
| format | Article |
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The Ab2 bound specifically to the Ab1 and their binding to Ab2 was inhibited by a recombinant fragment of gp120 (PB1) or a peptide (residues 301–324 of gp120), both expressing the Ab1-defined epitope. The Ab2 induced in rats antiantiidiotypic antibodies (Ab3) that were Ab1-like in their binding reactivities to PB1, native gp120 or peptide and shared idiotopes with the Ab1. However, the Ab2 did not induce virus-neutralizing Ab3, probably a reflection of the low avidity of the Ab3 as compared to the Ab1.</description><identifier>ISSN: 0882-8245</identifier><identifier>EISSN: 1557-8976</identifier><identifier>DOI: 10.1089/vim.1994.7.61</identifier><identifier>PMID: 7531443</identifier><identifier>CODEN: VIIMET</identifier><language>eng</language><publisher>New York, NY: Liebert</publisher><subject>AIDS/HIV ; Animals ; Antibodies, Anti-Idiotypic - biosynthesis ; Antibodies, Anti-Idiotypic - immunology ; Antibodies, immunoglobulins ; Binding, Competitive - immunology ; Biological and medical sciences ; Enzyme-Linked Immunosorbent Assay ; Epitopes - immunology ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetic markers (allotypes, idiotypes) ; HIV Antibodies - immunology ; HIV Envelope Protein gp120 - immunology ; HIV-1 - immunology ; Immunoglobulin G - immunology ; Molecular immunology ; Neutralization Tests ; Peptide Fragments - immunology ; Rabbits ; Rats ; Rats, Inbred Lew ; Recombinant Proteins - immunology</subject><ispartof>Viral immunology, 1994, Vol.7 (2), p.61-69</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2083-f2cc28b84b8d0cb629819bb3703b835f757e01c80bdbdb8f4aba8822857d384c3</citedby><cites>FETCH-LOGICAL-c2083-f2cc28b84b8d0cb629819bb3703b835f757e01c80bdbdb8f4aba8822857d384c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/vim.1994.7.61$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/vim.1994.7.61$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>315,781,785,3043,4025,21725,27925,27926,27927,55293,55305</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3313088$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7531443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SPERLAGH, M</creatorcontrib><creatorcontrib>HOXIE, J</creatorcontrib><creatorcontrib>MARUYAMA, H</creatorcontrib><creatorcontrib>STEFANO, K</creatorcontrib><creatorcontrib>GONZALES-SCARANO, F</creatorcontrib><creatorcontrib>PREWETT, M</creatorcontrib><creatorcontrib>SHAONONG LIANG</creatorcontrib><creatorcontrib>MATSUSHITA, S</creatorcontrib><creatorcontrib>HERLYN, D</creatorcontrib><title>Polyclonal Antiidiotypic Antibodies Mimicking gp120 of HIV-1</title><title>Viral immunology</title><addtitle>Viral Immunol</addtitle><description>Rabbit antiidiotypic antibodies (Ab2) were produced against anti-HIV-1 antibody 0.5β (Ab1), which binds to gp120 of HIV-1 and shows virus-neutralizing activity. The Ab2 bound specifically to the Ab1 and their binding to Ab2 was inhibited by a recombinant fragment of gp120 (PB1) or a peptide (residues 301–324 of gp120), both expressing the Ab1-defined epitope. The Ab2 induced in rats antiantiidiotypic antibodies (Ab3) that were Ab1-like in their binding reactivities to PB1, native gp120 or peptide and shared idiotopes with the Ab1. However, the Ab2 did not induce virus-neutralizing Ab3, probably a reflection of the low avidity of the Ab3 as compared to the Ab1.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antibodies, Anti-Idiotypic - biosynthesis</subject><subject>Antibodies, Anti-Idiotypic - immunology</subject><subject>Antibodies, immunoglobulins</subject><subject>Binding, Competitive - immunology</subject><subject>Biological and medical sciences</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epitopes - immunology</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genetic markers (allotypes, idiotypes)</subject><subject>HIV Antibodies - immunology</subject><subject>HIV Envelope Protein gp120 - immunology</subject><subject>HIV-1 - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>Molecular immunology</subject><subject>Neutralization Tests</subject><subject>Peptide Fragments - immunology</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Recombinant Proteins - immunology</subject><issn>0882-8245</issn><issn>1557-8976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQQBdRaq0ePQo5iLfE_UiyE_AiRW2hogf1uuxuNmU1ycZsKvTfu7WhV5nDMDOPmeEhdElwQjAUtz-2SUhRpAlPcnKEpiTLeAwFz4_RFAPQGGianaIz7z8xxpADm6AJzxhJUzZFd6-u3uratbKO7tvB2tK6YdtZ_VcpV1rjo2fbWP1l23W07gjFkauixfIjJufopJK1NxdjnqH3x4e3-SJevTwt5_erWFMMLK6o1hQUpApKrFVOCyCFUoxjpoBlFc-4wUQDVmUIqFKpZHicQsZLBqlmM3Sz39v17ntj_CAa67Wpa9kat_GCc044JTyA8R7UvfO-N5XoetvIfisIFjtbItgSO1uCi5wE_mpcvFGNKQ_0qCfMr8e59FrWVS9bbf0BY4ywoDhgbI_turJta2uU6Yd_jv8C5VCCGw</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>SPERLAGH, M</creator><creator>HOXIE, J</creator><creator>MARUYAMA, H</creator><creator>STEFANO, K</creator><creator>GONZALES-SCARANO, F</creator><creator>PREWETT, M</creator><creator>SHAONONG LIANG</creator><creator>MATSUSHITA, S</creator><creator>HERLYN, D</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Polyclonal Antiidiotypic Antibodies Mimicking gp120 of HIV-1</title><author>SPERLAGH, M ; HOXIE, J ; MARUYAMA, H ; STEFANO, K ; GONZALES-SCARANO, F ; PREWETT, M ; SHAONONG LIANG ; MATSUSHITA, S ; HERLYN, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2083-f2cc28b84b8d0cb629819bb3703b835f757e01c80bdbdb8f4aba8822857d384c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antibodies, Anti-Idiotypic - biosynthesis</topic><topic>Antibodies, Anti-Idiotypic - immunology</topic><topic>Antibodies, immunoglobulins</topic><topic>Binding, Competitive - immunology</topic><topic>Biological and medical sciences</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epitopes - immunology</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genetic markers (allotypes, idiotypes)</topic><topic>HIV Antibodies - immunology</topic><topic>HIV Envelope Protein gp120 - immunology</topic><topic>HIV-1 - immunology</topic><topic>Immunoglobulin G - immunology</topic><topic>Molecular immunology</topic><topic>Neutralization Tests</topic><topic>Peptide Fragments - immunology</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Recombinant Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SPERLAGH, M</creatorcontrib><creatorcontrib>HOXIE, J</creatorcontrib><creatorcontrib>MARUYAMA, H</creatorcontrib><creatorcontrib>STEFANO, K</creatorcontrib><creatorcontrib>GONZALES-SCARANO, F</creatorcontrib><creatorcontrib>PREWETT, M</creatorcontrib><creatorcontrib>SHAONONG LIANG</creatorcontrib><creatorcontrib>MATSUSHITA, S</creatorcontrib><creatorcontrib>HERLYN, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Viral immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SPERLAGH, M</au><au>HOXIE, J</au><au>MARUYAMA, H</au><au>STEFANO, K</au><au>GONZALES-SCARANO, F</au><au>PREWETT, M</au><au>SHAONONG LIANG</au><au>MATSUSHITA, S</au><au>HERLYN, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyclonal Antiidiotypic Antibodies Mimicking gp120 of HIV-1</atitle><jtitle>Viral immunology</jtitle><addtitle>Viral Immunol</addtitle><date>1994</date><risdate>1994</risdate><volume>7</volume><issue>2</issue><spage>61</spage><epage>69</epage><pages>61-69</pages><issn>0882-8245</issn><eissn>1557-8976</eissn><coden>VIIMET</coden><abstract>Rabbit antiidiotypic antibodies (Ab2) were produced against anti-HIV-1 antibody 0.5β (Ab1), which binds to gp120 of HIV-1 and shows virus-neutralizing activity. The Ab2 bound specifically to the Ab1 and their binding to Ab2 was inhibited by a recombinant fragment of gp120 (PB1) or a peptide (residues 301–324 of gp120), both expressing the Ab1-defined epitope. The Ab2 induced in rats antiantiidiotypic antibodies (Ab3) that were Ab1-like in their binding reactivities to PB1, native gp120 or peptide and shared idiotopes with the Ab1. However, the Ab2 did not induce virus-neutralizing Ab3, probably a reflection of the low avidity of the Ab3 as compared to the Ab1.</abstract><cop>New York, NY</cop><pub>Liebert</pub><pmid>7531443</pmid><doi>10.1089/vim.1994.7.61</doi><tpages>9</tpages></addata></record> |
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| ispartof | Viral immunology, 1994, Vol.7 (2), p.61-69 |
| issn | 0882-8245 1557-8976 |
| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | AIDS/HIV Animals Antibodies, Anti-Idiotypic - biosynthesis Antibodies, Anti-Idiotypic - immunology Antibodies, immunoglobulins Binding, Competitive - immunology Biological and medical sciences Enzyme-Linked Immunosorbent Assay Epitopes - immunology Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic markers (allotypes, idiotypes) HIV Antibodies - immunology HIV Envelope Protein gp120 - immunology HIV-1 - immunology Immunoglobulin G - immunology Molecular immunology Neutralization Tests Peptide Fragments - immunology Rabbits Rats Rats, Inbred Lew Recombinant Proteins - immunology |
| title | Polyclonal Antiidiotypic Antibodies Mimicking gp120 of HIV-1 |
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