Brain choline in depression: In vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy

1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in th...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 1994-11, Vol.18 (7), p.1121-1127
Hauptverfasser:	Charles, H.Cecil, Lazeyras, Francois, Krishnan, K.Ranga Rama, Boyko, Orest B., Payne, Martha, Moore, Debbie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aged Antidepressive Agents - therapeutic use Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Brain Chemistry - drug effects Brain Chemistry - physiology choline Choline - metabolism cholinergic system Depression Depressive Disorder - drug therapy Depressive Disorder - metabolism Depressive Disorder - psychology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging magnetic resonance spectroscopy Medical sciences Middle Aged Mood disorders N-acetyl aspartate Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
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Zusammenfassung:	1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.
ISSN:	0278-5846 1878-4216
DOI:	10.1016/0278-5846(94)90115-5