Synthesis and in vitro cytotoxic activity of aza- and diazaanthraquinone derivatives

Synthesis and in vitro cytotoxic activity of aza- and diazaanthraquinone derivatives

Some 1,4-dihydro aza- and 1,4-dihydro diazaanthraquinone derivatives have been synthesized and submitted to in vitro cytotoxicity tests towards L 1210, MDA-MB 231 and PC3 cell lines. Some of the new substances showed significant activity.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmazie 1994-11, Vol.49 (11), p.819-821
Hauptverfasser: NEBOIS, P, DO NASCIMENTO, S. C, BOITARD, M, BARTOLI, M.-H, FILLION, H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anthraquinones - chemical synthesis
Anthraquinones - pharmacology
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Biological and medical sciences
Drug Screening Assays, Antitumor
Female
General aspects
Humans
Leukemia L1210 - drug therapy
Male
Medical sciences
Mice
Pharmacology. Drug treatments
Tumor Cells, Cultured
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Some 1,4-dihydro aza- and 1,4-dihydro diazaanthraquinone derivatives have been synthesized and submitted to in vitro cytotoxicity tests towards L 1210, MDA-MB 231 and PC3 cell lines. Some of the new substances showed significant activity.
ISSN:0031-7144