Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
A broad spectrum of biological activities has been proposed for transforming growth factor-beta 3 (TGF-beta 3). To study TGF-beta 3 function in development, TGF-beta 3 null mutant mice were generated by gene-targeting. Within 20 hours of birth, homozygous TGF-beta 3-/- mice die with unique and consi...
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| Veröffentlicht in: | Nature genetics 1995-12, Vol.11 (4), p.415-421 |
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| container_title | Nature genetics |
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| creator | Kaartinen, V Voncken, J W Shuler, C Warburton, D Bu, D Heisterkamp, N Groffen, J |
| description | A broad spectrum of biological activities has been proposed for transforming growth factor-beta 3 (TGF-beta 3). To study TGF-beta 3 function in development, TGF-beta 3 null mutant mice were generated by gene-targeting. Within 20 hours of birth, homozygous TGF-beta 3-/- mice die with unique and consistent phenotypic features including delayed pulmonary development and defective palatogenesis. Unlike other null mutants with cleft palate, TGF-beta 3-/- mice lack other concomitant craniofacial abnormalities. This study demonstrates an essential function for TGF-beta 3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial-mesenchymal interaction. |
| doi_str_mv | 10.1038/ng1295-415 |
| format | Article |
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| ispartof | Nature genetics, 1995-12, Vol.11 (4), p.415-421 |
| issn | 1061-4036 |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Animals Animals, Newborn Base Sequence Cleft Palate - embryology Cleft Palate - genetics Epithelium - physiology Lung - abnormalities Lung - chemistry Lung - embryology Mesoderm - physiology Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Morphogenesis Palate - embryology Proteolipids - analysis Pulmonary Surfactants - analysis Transforming Growth Factor beta - genetics Transforming Growth Factor beta - physiology |
| title | Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction |
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