Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

A broad spectrum of biological activities has been proposed for transforming growth factor-beta 3 (TGF-beta 3). To study TGF-beta 3 function in development, TGF-beta 3 null mutant mice were generated by gene-targeting. Within 20 hours of birth, homozygous TGF-beta 3-/- mice die with unique and consi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 1995-12, Vol.11 (4), p.415-421
Hauptverfasser:	Kaartinen, V, Voncken, J W, Shuler, C, Warburton, D, Bu, D, Heisterkamp, N, Groffen, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Base Sequence Cleft Palate - embryology Cleft Palate - genetics Epithelium - physiology Lung - abnormalities Lung - chemistry Lung - embryology Mesoderm - physiology Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Morphogenesis Palate - embryology Proteolipids - analysis Pulmonary Surfactants - analysis Transforming Growth Factor beta - genetics Transforming Growth Factor beta - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A broad spectrum of biological activities has been proposed for transforming growth factor-beta 3 (TGF-beta 3). To study TGF-beta 3 function in development, TGF-beta 3 null mutant mice were generated by gene-targeting. Within 20 hours of birth, homozygous TGF-beta 3-/- mice die with unique and consistent phenotypic features including delayed pulmonary development and defective palatogenesis. Unlike other null mutants with cleft palate, TGF-beta 3-/- mice lack other concomitant craniofacial abnormalities. This study demonstrates an essential function for TGF-beta 3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial-mesenchymal interaction.
ISSN:	1061-4036
DOI:	10.1038/ng1295-415