Inhibitors of lipid peroxidation among new pyrimido[1',6':1,2]pyrido[3,4-b]indoles

A series of potent inhibitors of NADPH- and Fe(2+)-dependent lipid peroxidation has been found among new pyrimido[1'6':1,2]pyrido[3,4-b]indole derivatives. According to preliminary structure-activity relationship analysis the saturated pyrimidine moiety was responsible for this effect. Som...

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Veröffentlicht in:	Pharmazie 1994-11, Vol.49 (11), p.807-810
Hauptverfasser:	DOMANY, G, GERE, A, PAROCZAI, M, SZANTAY, C. S, FERENCZY, G. G, SCHÖN, I, KISS, B, KARPATI, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - metabolism Brain Ischemia - metabolism Craniocerebral Trauma - metabolism Female In Vitro Techniques Indoles - chemical synthesis Indoles - pharmacology Iron - metabolism Lipid Peroxidation - drug effects Male Medical sciences Mice Mice, Inbred Strains Microsomes - metabolism NADP - metabolism Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Rats Rats, Wistar Structure-Activity Relationship
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Zusammenfassung:	A series of potent inhibitors of NADPH- and Fe(2+)-dependent lipid peroxidation has been found among new pyrimido[1'6':1,2]pyrido[3,4-b]indole derivatives. According to preliminary structure-activity relationship analysis the saturated pyrimidine moiety was responsible for this effect. Some members of this family were effective in a bilateral carotid occlusion model in mice, and some derivatives showed protective effect in a mouse head injury model.
ISSN:	0031-7144