New anthracycline antibiotics 10-epi-oxaunomycin and 10-epi-11-deoxyoxaunomycin

Two new anthracycline antibiotics, 10-epi-oxaunomycin and 10-epi-11-deoxyoxaunomycin, were photochemically obtained from anthracycline metabolites D788-1 (10-carboxy-13-deoxocarminomy-cin) and D788-3 (10-carboxy-11-deoxy-13-deoxocarminomycin) and were examined for their growth inhibitory activities...

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Veröffentlicht in:	Journal of antibiotics 1995, Vol.48 (10), p.1153-1158
Hauptverfasser:	JOHDO, O, NISHIDA, H, OKAMOTO, R, YOSHIMOTO, A, TAKEUCHI, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracyclines - chemical synthesis Anthracyclines - chemistry Anthracyclines - pharmacology Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Chromatography, High Pressure Liquid General aspects Leukemia L1210 Medical sciences Molecular Conformation Pharmacology. Drug treatments Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Two new anthracycline antibiotics, 10-epi-oxaunomycin and 10-epi-11-deoxyoxaunomycin, were photochemically obtained from anthracycline metabolites D788-1 (10-carboxy-13-deoxocarminomy-cin) and D788-3 (10-carboxy-11-deoxy-13-deoxocarminomycin) and were examined for their growth inhibitory activities on cultured L1210 leukemic cells. Effects of the S configuration of C-10 and a hydroxyl group at C-11 on the bioactivity are discussed in comparison with oxaunomycin and 11-deoxyoxaunomycin.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.48.1153