The antimeningococcal vaccine VAMENGOC B-C induced poor serum and salivary antibody response in young Brazilian children

In 1989 about 2.3 million Brazilian children received the antimeningococcal vaccine VAMENGOC B-C (Havana, Cuba). We evaluated the serum and secretory immune response of vaccinated children by enzyme-linked immunosorbent assay with outer membrane complex antigens. Western blotting and bacterial adher...

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Veröffentlicht in:	The Pediatric infectious disease journal 1995-09, Vol.14 (9), p.797-803
Hauptverfasser:	CARBONARE, S B, ARSLANIAN, C, SILVA, M L. M, FARHAT, C K, CARNEIRO-SAMPAIO, M M. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bacterial - analysis Antibodies, Bacterial - biosynthesis Bacterial Adhesion Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Biological and medical sciences Blotting, Western Brazil Child Child, Preschool Female Human bacterial diseases Humans Infant Infectious diseases Male Medical sciences Meningitis, Meningococcal - immunology Meningitis, Meningococcal - prevention & control Meningococcal Vaccines Mouth Mucosa - microbiology Neisseria meningitidis Neisseria meningitidis - immunology Neisseria meningitidis - physiology Saliva - immunology Tropical medicine Vaccination
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Beschreibung
Zusammenfassung:	In 1989 about 2.3 million Brazilian children received the antimeningococcal vaccine VAMENGOC B-C (Havana, Cuba). We evaluated the serum and secretory immune response of vaccinated children by enzyme-linked immunosorbent assay with outer membrane complex antigens. Western blotting and bacterial adherence inhibition assays with human buccal epithelial cells were performed with some of the samples. Serum and salivary antibody concentrations to Neisseria meningitidis Group B of vaccinated children
ISSN:	0891-3668 1532-0987
DOI:	10.1097/00006454-199509000-00013