‘Increased calcium-current’ hypothesis of brain aging
Based on evidence that high Mg 2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca 2+-dependent K + currents, it is proposed that an underlying cause of altered Ca 2+ homeostasis during brain aging may be an increased membrane conduc...
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| Veröffentlicht in: | Neurobiology of aging 1987-07, Vol.8 (4), p.346-347 |
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| container_end_page | 347 |
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| container_issue | 4 |
| container_start_page | 346 |
| container_title | Neurobiology of aging |
| container_volume | 8 |
| creator | Landfield, Philip W. |
| description | Based on evidence that high Mg
2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca
2+-dependent K
+ currents, it is proposed that an underlying cause of altered Ca
2+ homeostasis during brain aging may be an increased membrane conductance to Ca
2+. An apparent Ca
2+-mediated inactivation of Ca
2+ current, which was recently described in hippocampus, could account for some of the contradictions in the literature. |
| doi_str_mv | 10.1016/0197-4580(87)90074-1 |
| format | Article |
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2+-dependent K
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2+ homeostasis during brain aging may be an increased membrane conductance to Ca
2+. An apparent Ca
2+-mediated inactivation of Ca
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2+-dependent K
+ currents, it is proposed that an underlying cause of altered Ca
2+ homeostasis during brain aging may be an increased membrane conductance to Ca
2+. An apparent Ca
2+-mediated inactivation of Ca
2+ current, which was recently described in hippocampus, could account for some of the contradictions in the literature.</description><subject>Aging - metabolism</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Calcium - metabolism</subject><subject>Cell Membrane - metabolism</subject><subject>Central nervous system</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Homeostasis</subject><subject>In Vitro Techniques</subject><subject>Neurons - metabolism</subject><subject>Rats</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9O3DAQh60KBFvaNyhSDgi1h9BxnPjPBQmhtiAhcWnPljMZg1E2WewEaW_7GO3r8SQk3dUeOc1hvt9vRh9jXzhccODyO3Cj8rLS8FWrbwZAlTn_wBa8qnTOS6MO2GKPHLOPKT3BDCl5xI6ELJSoYMHM6-bvbYeRXKImQ9diGJc5jjFSN7xu_mWP61U_PFIKKet9VkcXusw9hO7hEzv0rk30eTdP2J-fP35f3-R3979ur6_uchRaDrkBRAIBEgR51UADKArRVJrzGqUqvEZXoqnJa-_AoC5QNrz0xpUeai_FCTvf9q5i_zxSGuwyJKS2dR31Y7JKSVPxqpjAcgti7FOK5O0qhqWLa8vBzsbsrMPOOqxW9r8xy6fY6a5_rJfU7EM7RdP-bLd3afLjo-swpD2mBZ-a5uuXW4wmFy-Bok0YqENqQiQcbNOH9_94A-8wiLs</recordid><startdate>19870701</startdate><enddate>19870701</enddate><creator>Landfield, Philip W.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870701</creationdate><title>‘Increased calcium-current’ hypothesis of brain aging</title><author>Landfield, Philip W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-90cce030603ef7d0d0c323d5811bc672f8ca4c9bef8fa09c82c6d14f9a4f0bf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aging - metabolism</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>Calcium - metabolism</topic><topic>Cell Membrane - metabolism</topic><topic>Central nervous system</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Homeostasis</topic><topic>In Vitro Techniques</topic><topic>Neurons - metabolism</topic><topic>Rats</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landfield, Philip W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landfield, Philip W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>‘Increased calcium-current’ hypothesis of brain aging</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1987-07-01</date><risdate>1987</risdate><volume>8</volume><issue>4</issue><spage>346</spage><epage>347</epage><pages>346-347</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Based on evidence that high Mg
2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca
2+-dependent K
+ currents, it is proposed that an underlying cause of altered Ca
2+ homeostasis during brain aging may be an increased membrane conductance to Ca
2+. An apparent Ca
2+-mediated inactivation of Ca
2+ current, which was recently described in hippocampus, could account for some of the contradictions in the literature.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>3627350</pmid><doi>10.1016/0197-4580(87)90074-1</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 1987-07, Vol.8 (4), p.346-347 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77695152 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aging - metabolism Aging - physiology Animals Biological and medical sciences Brain - metabolism Brain - physiopathology Calcium - metabolism Cell Membrane - metabolism Central nervous system Electrophysiology Fundamental and applied biological sciences. Psychology Homeostasis In Vitro Techniques Neurons - metabolism Rats Vertebrates: nervous system and sense organs |
| title | ‘Increased calcium-current’ hypothesis of brain aging |
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