‘Increased calcium-current’ hypothesis of brain aging

Based on evidence that high Mg 2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca 2+-dependent K + currents, it is proposed that an underlying cause of altered Ca 2+ homeostasis during brain aging may be an increased membrane conduc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurobiology of aging 1987-07, Vol.8 (4), p.346-347
1. Verfasser:	Landfield, Philip W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - physiology Animals Biological and medical sciences Brain - metabolism Brain - physiopathology Calcium - metabolism Cell Membrane - metabolism Central nervous system Electrophysiology Fundamental and applied biological sciences. Psychology Homeostasis In Vitro Techniques Neurons - metabolism Rats Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Based on evidence that high Mg 2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca 2+-dependent K + currents, it is proposed that an underlying cause of altered Ca 2+ homeostasis during brain aging may be an increased membrane conductance to Ca 2+. An apparent Ca 2+-mediated inactivation of Ca 2+ current, which was recently described in hippocampus, could account for some of the contradictions in the literature.
ISSN:	0197-4580 1558-1497
DOI:	10.1016/0197-4580(87)90074-1