Small Cell Carcinoma of the Ovary of the Hypercalcemic Type: p53 Protein Accumulation and Clinicopathologic Features

Twenty women with ovarian small cell carcinoma of the hypercalcemic type were studied. Mean patient age was 24 years, 11 had hypercalcemia, and the 2-year actuarial survival was 18%; there was only one long-term survivor. Twelve of 15 tumors tested (80%) exhibited p53 protein accumulation by immunoh...

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Veröffentlicht in:	Gynecologic oncology 1995-11, Vol.59 (2), p.283-287
1. Verfasser:	SEIDMAN, JEFFREY D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Carcinoma, Small Cell - complications Carcinoma, Small Cell - metabolism Carcinoma, Small Cell - pathology Child Female Genital system. Mammary gland Humans Hypercalcemia - etiology Hypercalcemia - metabolism Investigative techniques, diagnostic techniques (general aspects) Medical sciences Ovarian Neoplasms - complications Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:	Twenty women with ovarian small cell carcinoma of the hypercalcemic type were studied. Mean patient age was 24 years, 11 had hypercalcemia, and the 2-year actuarial survival was 18%; there was only one long-term survivor. Twelve of 15 tumors tested (80%) exhibited p53 protein accumulation by immunohistochemistry, supporting the presence of p53 gene mutations in these tumors. p53 gene mutations may have an important role in the evolution of small cell ovarian carcinomas.
ISSN:	0090-8258 1095-6859
DOI:	10.1006/gyno.1995.0023