Cloning and Characterization of a Human cDNA (INPPL1) Sharing Homology with Inositol Polyphosphate Phosphatases

Cloning and Characterization of a Human cDNA (INPPL1) Sharing Homology with Inositol Polyphosphate Phosphatases

We have cloned a novel human cDNA, INPPL1 (GenBank Accession No. L36818), which maps to 11q23. The corresponding mRNA is 4657 nt in length and is widely expressed in both fetal and adult tissues. An open reading frame of 3441 nt encodes a putative polypeptide that shares several domains with inosito...

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Veröffentlicht in:Genomics 1995-09, Vol.29 (1), p.285-287
Hauptverfasser: Hejna, James A., Saito, Hiroshi, Merkens, Louise S., Tittle, Thomas V., Jakobs, Petra M., Whitney, Michael A., Grompe, Markus, Friedberg, Andrew S., Moses, Robb E.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Amino Acid Sequence
Animals
Biological and medical sciences
BIOLOGY AND MEDICINE, BASIC STUDIES
Chromosome Mapping
Chromosomes, Human, Pair 11
Cloning, Molecular
Conserved Sequence
DNA, Complementary
DNA-CLONING
Fetus
Fundamental and applied biological sciences. Psychology
GENE MUTATIONS
GENE REGULATION
Genes. Genome
GENETIC MAPPING
Hominidae - genetics
HUMAN CHROMOSOMES
Humans
INOSITOLS
MESSENGER-RNA
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Open Reading Frames
PHOSPHATASES
Phosphoric Monoester Hydrolases - biosynthesis
Phosphoric Monoester Hydrolases - genetics
Polymorphism, Genetic
POLYPEPTIDES
Sequence Homology, Amino Acid
SIZE
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Beschreibung
Zusammenfassung:We have cloned a novel human cDNA, INPPL1 (GenBank Accession No. L36818), which maps to 11q23. The corresponding mRNA is 4657 nt in length and is widely expressed in both fetal and adult tissues. An open reading frame of 3441 nt encodes a putative polypeptide that shares several domains with inositol triphosphate phosphatases. Several polymorphisms have been mapped to the 3′-untranslated region, yet the putative coding region showed no polymorphisms in nine independent cDNA samples.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1995.1247