Gonadotropin-releasing hormone neurons in the rhesus macaque are not immunoreactive for the estrogen receptor

The issue of whether gonadotropin-releasing hormone (GnRH) neurons in the primate contain the estrogen receptor was examined by immunocytochemistry using prepubertal and adult (intact and ovariectomized) female rhesus macaques. No GnRH neurons were found to contain nuclei that were immunoreactive fo...

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Veröffentlicht in:	Brain research 1995-07, Vol.685 (1), p.198-200
Hauptverfasser:	Sullivan, Kelli A., Witkin, Joan W., Ferin, Michel, Silverman, Ann-Judith
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Estrogen receptor Female Fundamental and applied biological sciences. Psychology Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - analysis Hormones and neuropeptides. Regulation Hypothalamus Hypothalamus. Hypophysis. Epiphysis. Urophysis Immunohistochemistry Macaca mulatta Macaca mulatta - metabolism Neurons - chemistry Ovary - physiology Preoptic area Receptors, Estrogen - analysis Rhesus macaque Sexual Maturation Species Specificity Vertebrates: endocrinology
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Zusammenfassung:	The issue of whether gonadotropin-releasing hormone (GnRH) neurons in the primate contain the estrogen receptor was examined by immunocytochemistry using prepubertal and adult (intact and ovariectomized) female rhesus macaques. No GnRH neurons were found to contain nuclei that were immunoreactive for the estrogen receptor. These results confirm in primates what has been reported in other species and leave open the question of how the effects of gonadal steroids on GnRH neurons are mediated.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(95)00352-Q