Activation of forebrain dopamine systems by phencyclidine and footshock stress: evidence for distinct mechanisms

Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine...

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Veröffentlicht in:	Psychopharmacologia 1987-01, Vol.93 (1), p.133-135
Hauptverfasser:	BOWERS, M. B. JR, BANNON, M. J, HOFFMAN, F. J. JR
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arousal - drug effects Biological and medical sciences Brain - drug effects Dopamine - metabolism Electroshock Homovanillic Acid - metabolism Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Phencyclidine - pharmacology Psychodysleptics: hallucinogen Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Receptors, Dopamine - drug effects Substance P - metabolism
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Zusammenfassung:	Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activate forebrain dopaminergic systems in part by separate mechanisms.
ISSN:	0033-3158 1432-2072
DOI:	10.1007/BF02439600