Bilateral subthalamic nucleus stimulation for severe Parkinson's disease

Subthalamic nucleus (STN) lesions or high‐frequency stimulations could improve parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure of chronic stimulation to the STN in severely disabled parkinsonian patients. This article presents the case of the first patient operated on...

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Veröffentlicht in:	Movement disorders 1995-09, Vol.10 (5), p.672-674
Hauptverfasser:	Limousin, Patricia, Pollak, Pierre, Benazzouz, Abdelhamid, Hoffmann, Dominique, Broussolle, Emmanuel, Perret, Jean Edmond, Benabid, Alim-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiparkinson Agents - administration & dosage Antiparkinson Agents - therapeutic use Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug Electric Stimulation Electrodes, Implanted Functional Laterality Humans Levodopa - administration & dosage Levodopa - therapeutic use Male Medical sciences Middle Aged Neurology Parkinson Disease - drug therapy Parkinson Disease - physiopathology Parkinson Disease - surgery Parkinson's disease Severity of Illness Index Stimulation Subthalamic nucleus Thalamic Nuclei
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Zusammenfassung:	Subthalamic nucleus (STN) lesions or high‐frequency stimulations could improve parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure of chronic stimulation to the STN in severely disabled parkinsonian patients. This article presents the case of the first patient operated on bilaterally. Bilateral STN stimulation has greatly improved akinesia and rigidity. The benefit was maintained ≤15 months after surgery. Unilateral stimulation induced motor effects mainly in contralateral limbs. Further studies are needed to evaluate the value of this procedure in the treatment of Parkinson's disease.
ISSN:	0885-3185 1531-8257
DOI:	10.1002/mds.870100523