Efficacy of a Single Intravenous Dose of Amphotericin B in Urinary Tract Infections Caused by Candida
Studies in experimental animals and humans have demonstrated that amphotericin B (AmB) may be detectable in urine for several days to weeks following a single iv dose. Moreover, for prolonged periods, urine levels of AmB exceed the MIC reported for prolonged periods, urine levels of AmB exceed the M...
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| Veröffentlicht in: | The Journal of infectious diseases 1987-10, Vol.156 (4), p.685-685 |
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| container_end_page | 685 |
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| container_issue | 4 |
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| container_title | The Journal of infectious diseases |
| container_volume | 156 |
| creator | Fisher, John F. Hicks, Biram C. Dipiro, Joseph T. Venable, Josef Fincher, Ruth-Marie E. |
| description | Studies in experimental animals and humans have demonstrated that amphotericin B (AmB) may be detectable in urine for several days to weeks following a single iv dose. Moreover, for prolonged periods, urine levels of AmB exceed the MIC reported for prolonged periods, urine levels of AmB exceed the MIC reported for many species of Candida . These findings suggest that the slow renal excretion of AmB could be advantageously used to treat urinary tract infections caused by Candida , irrespective of their location in the urinary tract. To test this hypothesis, the authors have begun a study using a single therapeutic dose of AmB in patients with persistent candiduria. They report here their preliminary data. |
| doi_str_mv | 10.1093/infdis/156.4.685 |
| format | Article |
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Moreover, for prolonged periods, urine levels of AmB exceed the MIC reported for prolonged periods, urine levels of AmB exceed the MIC reported for many species of Candida . These findings suggest that the slow renal excretion of AmB could be advantageously used to treat urinary tract infections caused by Candida , irrespective of their location in the urinary tract. To test this hypothesis, the authors have begun a study using a single therapeutic dose of AmB in patients with persistent candiduria. They report here their preliminary data.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/156.4.685</identifier><identifier>PMID: 3624910</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University Chicago Press</publisher><subject>Amphotericin B - therapeutic use ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Biological and medical sciences ; Candida ; Candidiasis - drug therapy ; Correspondence ; Diabetes mellitus ; Dosage ; Excretion ; Humans ; Infections ; Medical sciences ; Medical treatment ; Pharmacology. Drug treatments ; Urinary bladder ; Urinary tract ; Urinary tract infections ; Urinary Tract Infections - drug therapy ; Urine</subject><ispartof>The Journal of infectious diseases, 1987-10, Vol.156 (4), p.685-685</ispartof><rights>Copyright 1987 The University of Chicago</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-98cd410f5fafdf84ffef4a06d9fd5967446bcdc785df3c36a20bd3ac394a85c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30136577$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30136577$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7732848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3624910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fisher, John F.</creatorcontrib><creatorcontrib>Hicks, Biram C.</creatorcontrib><creatorcontrib>Dipiro, Joseph T.</creatorcontrib><creatorcontrib>Venable, Josef</creatorcontrib><creatorcontrib>Fincher, Ruth-Marie E.</creatorcontrib><title>Efficacy of a Single Intravenous Dose of Amphotericin B in Urinary Tract Infections Caused by Candida</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Studies in experimental animals and humans have demonstrated that amphotericin B (AmB) may be detectable in urine for several days to weeks following a single iv dose. Moreover, for prolonged periods, urine levels of AmB exceed the MIC reported for prolonged periods, urine levels of AmB exceed the MIC reported for many species of Candida . These findings suggest that the slow renal excretion of AmB could be advantageously used to treat urinary tract infections caused by Candida , irrespective of their location in the urinary tract. To test this hypothesis, the authors have begun a study using a single therapeutic dose of AmB in patients with persistent candiduria. They report here their preliminary data.</description><subject>Amphotericin B - therapeutic use</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Biological and medical sciences</subject><subject>Candida</subject><subject>Candidiasis - drug therapy</subject><subject>Correspondence</subject><subject>Diabetes mellitus</subject><subject>Dosage</subject><subject>Excretion</subject><subject>Humans</subject><subject>Infections</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Pharmacology. Drug treatments</subject><subject>Urinary bladder</subject><subject>Urinary tract</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - drug therapy</subject><subject>Urine</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1vUzEUxS0EKmlgZ0HygNhear_rz7GEllRqxUArVSyW4w9wSfxS-wWR_x5HCe3Icn2lc85Puj4IvaNkRomGs5SjT_WMcjFjM6H4CzShHGQnBIWXaEJI33dUaf0andb6QAhhIOQJOgHRM03JBIWLGJOzboeHiC3-lvKPVcBXeSz2d8jDtuLPQw178Xy9-TmMoSSXMv6E27grKduyw7fFurFlYnBjGnLFc7utwePlrm3ZJ2_foFfRrmp4e3yn6O7y4na-6K6_frman193DpQaO62cZ5REHm30UbEYQ2SWCK-j51pIxsTSeScV9xEcCNuTpQfrQDOruFMwRR8P3E0ZHrehjmadqgurlc2h3WKkFIIrDf81UqZ6CbAnkoPRlaHWEqLZlLRuVxtKzL4Cc6jAtAoMM62CFnl_ZG-X6-CfAsc_b_qHo26rs6tYbHYN8M8mJfSKqWfMQx2H8kwhFARvpinqDnqqY_jzpNvyywgJkpvF_XezkDcc9PzG3MNfjyupVg</recordid><startdate>19871001</startdate><enddate>19871001</enddate><creator>Fisher, John F.</creator><creator>Hicks, Biram C.</creator><creator>Dipiro, Joseph T.</creator><creator>Venable, Josef</creator><creator>Fincher, Ruth-Marie E.</creator><general>The University Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19871001</creationdate><title>Efficacy of a Single Intravenous Dose of Amphotericin B in Urinary Tract Infections Caused by Candida</title><author>Fisher, John F. ; Hicks, Biram C. ; Dipiro, Joseph T. ; Venable, Josef ; Fincher, Ruth-Marie E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-98cd410f5fafdf84ffef4a06d9fd5967446bcdc785df3c36a20bd3ac394a85c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Amphotericin B - therapeutic use</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Biological and medical sciences</topic><topic>Candida</topic><topic>Candidiasis - drug therapy</topic><topic>Correspondence</topic><topic>Diabetes mellitus</topic><topic>Dosage</topic><topic>Excretion</topic><topic>Humans</topic><topic>Infections</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Pharmacology. Drug treatments</topic><topic>Urinary bladder</topic><topic>Urinary tract</topic><topic>Urinary tract infections</topic><topic>Urinary Tract Infections - drug therapy</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fisher, John F.</creatorcontrib><creatorcontrib>Hicks, Biram C.</creatorcontrib><creatorcontrib>Dipiro, Joseph T.</creatorcontrib><creatorcontrib>Venable, Josef</creatorcontrib><creatorcontrib>Fincher, Ruth-Marie E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fisher, John F.</au><au>Hicks, Biram C.</au><au>Dipiro, Joseph T.</au><au>Venable, Josef</au><au>Fincher, Ruth-Marie E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of a Single Intravenous Dose of Amphotericin B in Urinary Tract Infections Caused by Candida</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1987-10-01</date><risdate>1987</risdate><volume>156</volume><issue>4</issue><spage>685</spage><epage>685</epage><pages>685-685</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Studies in experimental animals and humans have demonstrated that amphotericin B (AmB) may be detectable in urine for several days to weeks following a single iv dose. Moreover, for prolonged periods, urine levels of AmB exceed the MIC reported for prolonged periods, urine levels of AmB exceed the MIC reported for many species of Candida . These findings suggest that the slow renal excretion of AmB could be advantageously used to treat urinary tract infections caused by Candida , irrespective of their location in the urinary tract. To test this hypothesis, the authors have begun a study using a single therapeutic dose of AmB in patients with persistent candiduria. They report here their preliminary data.</abstract><cop>Chicago, IL</cop><pub>The University Chicago Press</pub><pmid>3624910</pmid><doi>10.1093/infdis/156.4.685</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1987-10, Vol.156 (4), p.685-685 |
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| language | eng |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Amphotericin B - therapeutic use Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences Candida Candidiasis - drug therapy Correspondence Diabetes mellitus Dosage Excretion Humans Infections Medical sciences Medical treatment Pharmacology. Drug treatments Urinary bladder Urinary tract Urinary tract infections Urinary Tract Infections - drug therapy Urine |
| title | Efficacy of a Single Intravenous Dose of Amphotericin B in Urinary Tract Infections Caused by Candida |
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