Analysis of immunoglobulin gene rearrangements in single B cells

Analysis of immunoglobulin gene rearrangements in single B cells

The polymerase chain reaction allows the characterization of RNA and DNA sequences in samples as small as a single cell. The recent development of amplification systems designed to isolate rearranged immunoglobulin genes from single B lineage cells has provided a powerful tool to investigate various...

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Veröffentlicht in:Current opinion in immunology 1995-04, Vol.7 (2), p.281-284
Hauptverfasser: Ehlich, Andreas, Küppers, Ralf
Format: Artikel
Sprache:eng
Schlagworte:
Animals
B-Lymphocytes - chemistry
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region - genetics
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Beschreibung
Zusammenfassung:The polymerase chain reaction allows the characterization of RNA and DNA sequences in samples as small as a single cell. The recent development of amplification systems designed to isolate rearranged immunoglobulin genes from single B lineage cells has provided a powerful tool to investigate various aspects of B-cell development.
ISSN:0952-7915
1879-0372
DOI:10.1016/0952-7915(95)80016-6