The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype
The extent of deposition of amyloid β protein (Aβ) was investigated in 20 elderly patients with Down's syndrome, using the endspecific monoclonal antibodies BC05 and BA27 to detect the presence of A β 42(43) and A β 40 (respectively), and related to apolipoprotein E (ApoE) genotype. No signific...
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Veröffentlicht in: | Neuroscience letters 1995-08, Vol.196 (1), p.105-108 |
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Sprache: | eng |
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Zusammenfassung: | The extent of deposition of amyloid β protein (Aβ) was investigated in 20 elderly patients with Down's syndrome, using the endspecific monoclonal antibodies BC05 and BA27 to detect the presence of A
β
42(43) and A
β
40 (respectively), and related to apolipoprotein E (ApoE) genotype. No significant differences in the amount of Aβ deposited in the brain, either as A
β
42(43) or A
β
40 were noted in patients possessing an ApoE E4 allele, compared to those without. Patients with an ApoE E4 allele in general died at an earlier age than those with only ApoE E3 alleles, the latter in turn being outlived by those with an ApoE E2 allele. In Down's syndrome therefore, ApoE may influence the timing of onset, or the rate of progression, of disease but without affecting the type or total amount of pathology accumulated. |
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ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/0304-3940(95)11860-Y |