Components of the GE2270 complex produced by Planobispora rosea ATCC 53773

Antibiotic GE2270A inhibits bacterial protein biosynthesis by acting on EF-Tu. The antibiotic has a thiazolyl peptide structure which has been recently revised. Other structurally related antibiotics are normally co-produced with GE2270A by Planobispora rosea ATCC 53773. We describe the isolation an...

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Veröffentlicht in:	Journal of antibiotics 1995-01, Vol.48 (9), p.1039-1042
Hauptverfasser:	Selva, E, Ferrari, P, Kurz, M, Tavecchia, P, Colombo, L, Stella, S, Restelli, E, Goldstein, B P, Ripamonti, F, Denaro, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - metabolism Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Chromatography, High Pressure Liquid Fermentation Microbial Sensitivity Tests Molecular Structure Peptides, Cyclic Spectrometry, Mass, Fast Atom Bombardment Structure-Activity Relationship Thiazoles - chemistry Thiazoles - pharmacology
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Zusammenfassung:	Antibiotic GE2270A inhibits bacterial protein biosynthesis by acting on EF-Tu. The antibiotic has a thiazolyl peptide structure which has been recently revised. Other structurally related antibiotics are normally co-produced with GE2270A by Planobispora rosea ATCC 53773. We describe the isolation and characterization of GE2270 factors E, D1, D2, C1, C2a, C2b, B1, B2 and T.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.48.1039