Ascorbic acid, redox cycling, lipid peroxidation, and the binding of dopamine receptor antagonists

The mammalian brain contains relatively high concentrations of ascorbic acid. The precise function of ascorbic acid in the central nervous system is at present unexplained. Most theories focus in some way on its reducing properties. Ascorbic acid is a relatively good reducing agent, and because of t...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1987, Vol.498 (1), p.63-76
Hauptverfasser:	Heikkila, R.E, Manzino, L
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE ASCORBIQUE ACIDO ASCORBICO Animals ANTAGONISM ANTAGONISME ANTAGONISMO ASCORBIC ACID Ascorbic Acid - pharmacology Cell Membrane - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism Domperidone - metabolism DOPAMINA DOPAMINE Dopamine Antagonists Lipid Peroxides - metabolism LIPIDE LIPIDOS LIPIDS Male OXIDACION OXIDATION Oxidation-Reduction OXYDATION Rats Rats, Inbred Strains Receptors, Dopamine - metabolism REDUCCION REDUCTION Spiperone - metabolism
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Beschreibung
Zusammenfassung:	The mammalian brain contains relatively high concentrations of ascorbic acid. The precise function of ascorbic acid in the central nervous system is at present unexplained. Most theories focus in some way on its reducing properties. Ascorbic acid is a relatively good reducing agent, and because of this property, it is often utilized to prevent unwanted oxidation processes.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.1987.tb23751.x