Anti-inflammatory activity of an orally active peptide sequence from PF-4 on acute inflammation and DTH
CT-112 is an octapeptide with the sequence TTSQVRPR. This sequence is found in at least human platelet factor 4 (PF-4). PF-4 is a member of the alpha -chemokine family. The biological activity associate with CT-112 has been explored in two models of inflammation. CT-112 has been found to possess ant...
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| Veröffentlicht in: | Inflammation research 1995-08, Vol.44 Suppl 2 (S2), p.S199-S200 |
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| container_end_page | S200 |
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| container_issue | S2 |
| container_start_page | S199 |
| container_title | Inflammation research |
| container_volume | 44 Suppl 2 |
| creator | Talmadge, J E Kelsey, L S Brown, G S Counts, D F |
| description | CT-112 is an octapeptide with the sequence TTSQVRPR. This sequence is found in at least human platelet factor 4 (PF-4). PF-4 is a member of the alpha -chemokine family. The biological activity associate with CT-112 has been explored in two models of inflammation. CT-112 has been found to possess anti-inflammatory properties due to modulation of the biological responses associated with both neutrophils (acute dermal inflammation in response to topical application of arachidonic acid) and T-cells (delayed type hypersensitivity). |
| doi_str_mv | 10.1007/BF01778331 |
| format | Article |
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This sequence is found in at least human platelet factor 4 (PF-4). PF-4 is a member of the alpha -chemokine family. The biological activity associate with CT-112 has been explored in two models of inflammation. 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This sequence is found in at least human platelet factor 4 (PF-4). PF-4 is a member of the alpha -chemokine family. The biological activity associate with CT-112 has been explored in two models of inflammation. 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This sequence is found in at least human platelet factor 4 (PF-4). PF-4 is a member of the alpha -chemokine family. The biological activity associate with CT-112 has been explored in two models of inflammation. CT-112 has been found to possess anti-inflammatory properties due to modulation of the biological responses associated with both neutrophils (acute dermal inflammation in response to topical application of arachidonic acid) and T-cells (delayed type hypersensitivity).</abstract><cop>Switzerland</cop><pmid>8548397</pmid><doi>10.1007/BF01778331</doi></addata></record> |
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| identifier | ISSN: 1023-3830 |
| ispartof | Inflammation research, 1995-08, Vol.44 Suppl 2 (S2), p.S199-S200 |
| issn | 1023-3830 1420-908X |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aldehyde Reductase - pharmacology Amino Acid Sequence Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Blood Proteins - biosynthesis Edema - chemically induced Edema - drug therapy Enzyme Inhibitors - pharmacology Female Hypersensitivity, Delayed - drug therapy Inflammation - drug therapy Mice Mice, Inbred C57BL Molecular Sequence Data Prednisone - pharmacology Thiazoles - pharmacology Thiazolidinediones |
| title | Anti-inflammatory activity of an orally active peptide sequence from PF-4 on acute inflammation and DTH |
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