A hypothetical model on the mechanism of anesthesia

An hypothesis on the mechanism of action of general anesthetic agents is proposed. It is based on a potentiation of chloride influx due to the action of anesthetic agents on the GABA-receptor complex at the lipid-protein interface. This hypothesis accomodates various observations such as lipid solub...

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Veröffentlicht in:	Medical hypotheses 1987-05, Vol.23 (1), p.1-9
Hauptverfasser:	Cheng, Sze-Chuh, Brunner, Edward A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia, General Anesthetics - pharmacology Animals Chlorides - metabolism gamma-Aminobutyric Acid - metabolism Ion Channels - metabolism Lipid Bilayers - metabolism Models, Biological Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism
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Beschreibung
Zusammenfassung:	An hypothesis on the mechanism of action of general anesthetic agents is proposed. It is based on a potentiation of chloride influx due to the action of anesthetic agents on the GABA-receptor complex at the lipid-protein interface. This hypothesis accomodates various observations such as lipid solubility of anesthetic molecules, their lack of stringent structural requirement, pressure reversal of anesthetic action, and other neurochemical and neuropharmacological data.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/0306-9877(87)90174-5