ACUTE HAEMODYNAMIC AND HORMONAL EFFECTS OF ORAL DOXAZOSIN IN NORMAL SUBJECTS

SUMMARY 1. Haemodynamic and hormonal effects of doxazosin, a long‐acting α1‐adrenoceptor antagonist (2 mg) were compared with placebo in six normal men. 2. Doxazosin at 2 mg produced lower supine systolic blood pressure and plasma cortisol concentration than control at 4 h only, but these changes were not sustained. Both supine and standing pulse rate were increased by active drug after 6 h. 3. In this acute study doxazosin did not affect plasma renin or aldosterone concentrations.