A polyclonal antibody raised against clonidine: a model for the specific imidazoline receptor
A partially purified bovine brain extract specifically interferes with clonidine at such receptors and more particularly, within the brainstem, with a subpopulation which proved insensitive to noradrenaline. This extract, which is not a catecholamine, was called "clonidine displacing substance&...
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| Veröffentlicht in: | European journal of pharmacology 1987-05, Vol.137 (1), p.143-144 |
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| container_end_page | 144 |
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| container_issue | 1 |
| container_start_page | 143 |
| container_title | European journal of pharmacology |
| container_volume | 137 |
| creator | Dontenwill, Monique Bricca, Giampiero Molines, Annick Belcourt, Alain Bousquet, Pascal |
| description | A partially purified bovine brain extract specifically interferes with clonidine at such receptors and more particularly, within the brainstem, with a subpopulation which proved insensitive to noradrenaline. This extract, which is not a catecholamine, was called "clonidine displacing substance" (CDS). Specific antibodies to clonidine were obtained. |
| doi_str_mv | 10.1016/0014-2999(87)90195-6 |
| format | Article |
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This extract, which is not a catecholamine, was called "clonidine displacing substance" (CDS). Specific antibodies to clonidine were obtained.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(87)90195-6</identifier><identifier>PMID: 3038575</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; antibodies ; Antibodies - immunology ; Antihypertensive agents ; Biological and medical sciences ; brain ; Cardiovascular system ; clonidine ; Clonidine - immunology ; Clonidine - metabolism ; Imidazoline Receptors ; In Vitro Techniques ; Medical sciences ; Pharmacology. 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This extract, which is not a catecholamine, was called "clonidine displacing substance" (CDS). Specific antibodies to clonidine were obtained.</description><subject>Animals</subject><subject>antibodies</subject><subject>Antibodies - immunology</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Cardiovascular system</subject><subject>clonidine</subject><subject>Clonidine - immunology</subject><subject>Clonidine - metabolism</subject><subject>Imidazoline Receptors</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Receptors, Adrenergic, alpha - analysis</subject><subject>Receptors, Adrenergic, alpha-2</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoO4rOPoP1DIQUQPvSbd-eh4EJbFj4WFvehRQnVS0Ui60yY9wvjr7XGGOeqhqMP7vEXxEPKMsyvOuHrDGBdNa4x51evXhnEjG_WAbHivTcM0bx-SzRl5RB7X-oMxJk0rL8llx7pearkhX6_pnNPepTxBojAtcch-TwvEip7CN4hTXeghjj5O-JYCHbPHREMudPmOtM7oYoiOxjF6-J3TStGCDucllyfkIkCq-PS0t-TLh_efbz41d_cfb2-u7xonuF4aw43zUge-TpDgMPAwhN63AgLHIbQolRu6VpgQhHEtdCYoNEM3KAQvsduSl8e7c8k_d1gXO8bqMCWYMO-q1Vq1vWDmvyAXRnGlxAqKI-hKrrVgsHOJI5S95cwe9NuDW3twa3tt_-q3aq09P93fDSP6c-nke81fnHKoDlIoMLlYz5iWqucruyXvjhiu0n5FLLa6iJNDH1e1i_U5_vuPP7J2ot8</recordid><startdate>19870507</startdate><enddate>19870507</enddate><creator>Dontenwill, Monique</creator><creator>Bricca, Giampiero</creator><creator>Molines, Annick</creator><creator>Belcourt, Alain</creator><creator>Bousquet, Pascal</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19870507</creationdate><title>A polyclonal antibody raised against clonidine: a model for the specific imidazoline receptor</title><author>Dontenwill, Monique ; Bricca, Giampiero ; Molines, Annick ; Belcourt, Alain ; Bousquet, Pascal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-919cd57f157ff5acef1fbf8d24af1ebf2e56cb3249ff49c2a39f6e9b3b6ead5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>antibodies</topic><topic>Antibodies - immunology</topic><topic>Antihypertensive agents</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Cardiovascular system</topic><topic>clonidine</topic><topic>Clonidine - immunology</topic><topic>Clonidine - metabolism</topic><topic>Imidazoline Receptors</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Receptors, Adrenergic, alpha - analysis</topic><topic>Receptors, Adrenergic, alpha-2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dontenwill, Monique</creatorcontrib><creatorcontrib>Bricca, Giampiero</creatorcontrib><creatorcontrib>Molines, Annick</creatorcontrib><creatorcontrib>Belcourt, Alain</creatorcontrib><creatorcontrib>Bousquet, Pascal</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dontenwill, Monique</au><au>Bricca, Giampiero</au><au>Molines, Annick</au><au>Belcourt, Alain</au><au>Bousquet, Pascal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A polyclonal antibody raised against clonidine: a model for the specific imidazoline receptor</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1987-05-07</date><risdate>1987</risdate><volume>137</volume><issue>1</issue><spage>143</spage><epage>144</epage><pages>143-144</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>A partially purified bovine brain extract specifically interferes with clonidine at such receptors and more particularly, within the brainstem, with a subpopulation which proved insensitive to noradrenaline. This extract, which is not a catecholamine, was called "clonidine displacing substance" (CDS). Specific antibodies to clonidine were obtained.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3038575</pmid><doi>10.1016/0014-2999(87)90195-6</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1987-05, Vol.137 (1), p.143-144 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals antibodies Antibodies - immunology Antihypertensive agents Biological and medical sciences brain Cardiovascular system clonidine Clonidine - immunology Clonidine - metabolism Imidazoline Receptors In Vitro Techniques Medical sciences Pharmacology. Drug treatments Rabbits Receptors, Adrenergic, alpha - analysis Receptors, Adrenergic, alpha-2 |
| title | A polyclonal antibody raised against clonidine: a model for the specific imidazoline receptor |
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