Intratympanic Injection of Sodium Arsanilate (Atoxyl) Solution Results in Postural Changes Consistent With Changes Described for Labyrinthectomized Rats

Intratympanic injections of sodium arsanilate (atoxyl) have been shown to produce vestibular dysfunction in the rat. Unilateral and bilateral dysfunction can be distinguished by changes in the animals' postures. These changes are consistent with changes described for unilateral or bilateral lab...

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Veröffentlicht in:	Behavioral neuroscience 1987-06, Vol.101 (3), p.427-428
Hauptverfasser:	Hunt, Mary A, Miller, S. Walden, Nielson, H. Clarke, Horn, Kris M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Animals Arsanilic Acid - administration & dosage Arsenicals - administration & dosage Biological and medical sciences Ear, Inner - drug effects Ear, Middle - drug effects Fundamental and applied biological sciences. Psychology Methodology Middle Ear Motor Activity - drug effects Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Postural Balance - drug effects Posture Rats Toxins Vertebrates: nervous system and sense organs Vestibular Apparatus
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Zusammenfassung:	Intratympanic injections of sodium arsanilate (atoxyl) have been shown to produce vestibular dysfunction in the rat. Unilateral and bilateral dysfunction can be distinguished by changes in the animals' postures. These changes are consistent with changes described for unilateral or bilateral labyrinthectomized rats. The intratympanic injection technique offers a simple yet effective alternative to labyrinthectomy.
ISSN:	0735-7044 1939-0084
DOI:	10.1037/0735-7044.101.3.427