Chrysospermins, new peptaibol antibiotics from Apiocrea chrysosperma Ap101

Four new members of peptaibol antibiotics, designated as chrysospermins A, B, C, and D, were isolated from the mycelium of Apiocrea chrysosperma Ap101 by solvent extraction, silica gel chromatography and preparative recycling HPLC. Their structures as new nonadecapeptides were settled by detailed sp...

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Veröffentlicht in:	Journal of antibiotics 1995, Vol.48 (9), p.977-989
Hauptverfasser:	DORNBERGER, K, IHN, W, RITZAU, M, GRÄFE, U, SCHLEGEL, B, FLECK, W. F, METZGER, J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - analysis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Ascomycota Biological and medical sciences Fermentation Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Molecular Sequence Data Peptides - chemistry Peptides - isolation & purification Peptides - pharmacology Pharmacology. Drug treatments Spectrometry, Mass, Fast Atom Bombardment
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Zusammenfassung:	Four new members of peptaibol antibiotics, designated as chrysospermins A, B, C, and D, were isolated from the mycelium of Apiocrea chrysosperma Ap101 by solvent extraction, silica gel chromatography and preparative recycling HPLC. Their structures as new nonadecapeptides were settled by detailed spectroscopic analysis and chemical degradation experiments. The chrysospermins display antibacterial and antifungal activity, and induce pigment formation by the fungus Phoma destructiva.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.48.977