Anti-lipoperoxidation action of food restriction

Chronic food restriction inhibited the age-related increase of malondialdehyde production and lipid hydroperoxides in liver mitochondrial and microsomal membranes of ad libitum fed Fischer 344 rats. The anti-lipoperoxidation action of food restriction could not be attributable to the changes in memb...

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Veröffentlicht in:	Biochemical and biophysical research communications 1987-06, Vol.145 (3), p.1185-1191
Hauptverfasser:	Laganiere, Serge, Yu, Byung P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Applied sciences Diet, Reducing Exact sciences and technology Intracellular Membranes - metabolism Kinetics Lipid Peroxides - metabolism Liver - growth & development Male Malondialdehyde - metabolism Microsomes, Liver - metabolism Mitochondria, Liver - metabolism Other techniques and industries Rats Rats, Inbred F344 Submitochondrial Particles - metabolism
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Beschreibung
Zusammenfassung:	Chronic food restriction inhibited the age-related increase of malondialdehyde production and lipid hydroperoxides in liver mitochondrial and microsomal membranes of ad libitum fed Fischer 344 rats. The anti-lipoperoxidation action of food restriction could not be attributable to the changes in membrane lipid content nor vitamin E status. Restricting calories modified membrane fatty acid composition by increasing linoleic acid and decreasing docosapentaenoic acid content in both membranes. The significance of the fatty acid modification was discussed in terms of anti-lipoperoxidation and membrane fluidity.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(87)91562-2