Treatment of bacillary dysentery: a comparison between enoxacin and nalidixic acid

A prospective randomized study has been conducted in Rwanda to compare the efficacy of enoxacin versus nalidixic acid for the treatment of bacillary dysentery in adults. Seventeen patients received nalidixic acid and 21 received enoxacin. All isolates (37 shigella, 1 campylobacter) were sensitive in...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1987-05, Vol.19 (5), p.695-698
Hauptverfasser:	De Mol, Patrick, Mets, Tony, Lagasse, Raphaël, Vandepitte, Joseph, Mutwewingabo, Anthère, Butzler, Jean-Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Campylobacter Clinical Trials as Topic Drug Resistance, Microbial Dysentery, Bacillary - drug therapy Enoxacin Humans Medical sciences Middle Aged Nalidixic Acid - therapeutic use Naphthyridines - therapeutic use Pharmacology. Drug treatments Prospective Studies Random Allocation Shigella Shigella dysenteriae - drug effects Shigella flexneri - drug effects
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Zusammenfassung:	A prospective randomized study has been conducted in Rwanda to compare the efficacy of enoxacin versus nalidixic acid for the treatment of bacillary dysentery in adults. Seventeen patients received nalidixic acid and 21 received enoxacin. All isolates (37 shigella, 1 campylobacter) were sensitive in vitro to the two drugs. All patients showed a favourable clinical and bacteriological response and the results obtained with both drugs were comparable. Enoxacin seems to be a good alternative to nalidixic acid for bacillary dysentery due to multiresistant shigella.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/19.5.695