High Performance Liquid Chromatography Assay for Piroxicam in Pharmaceutical Products

A high performance liquid chromatographic assay for piroxicam in pharmaceutical preparations is described. The method uses a reversed-phase C18 column with pH 3 aqueous buffer/methanol, 55:45, v/v mobile phase, and is selective for piroxicam in the presence of other “oxicams,” synthetic precursors,...

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Veröffentlicht in:	Journal of chromatographic science 1987-07, Vol.25 (7), p.292-295
Hauptverfasser:	Richards, Jeffrey A., Cole, Dale A., Hickey, Robert J., Sokol, Lucia S-W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed - analysis Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Capsules Chromatography, High Pressure Liquid Drug Stability Hydrogen-Ion Concentration Medical sciences Ointments Ophthalmic Solutions Pharmacology. Drug treatments Piroxicam - administration & dosage Piroxicam - analysis Spectrophotometry, Ultraviolet Suppositories
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Beschreibung
Zusammenfassung:	A high performance liquid chromatographic assay for piroxicam in pharmaceutical preparations is described. The method uses a reversed-phase C18 column with pH 3 aqueous buffer/methanol, 55:45, v/v mobile phase, and is selective for piroxicam in the presence of other “oxicams,” synthetic precursors, by-products, degradation products, metabolites, and related compounds. Applications to capsules, tablets, ointments, suppositories, ophthalmic suspensions, and rodent feeds are cited.
ISSN:	0021-9665 1945-239X
DOI:	10.1093/chromsci/25.7.292