The effect of diazepam and Ro 15–1788 on extracellular ascorbic acid, DOPAC and 5-HIAA in the striatum of anaesthetized and conscious freely moving rats, as measured by differential pulse voltammetry

The effects of diazepam (10 mg/kg i.p.) and the central benzodiazepine receptor antagonist, Ro 15–1788 (30 mg/kg i.p.), on extracellular ascorbate, 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) were examined using differential pulse voltammetry in anaesthetized and f...

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Veröffentlicht in:Neuroscience research 1987-04, Vol.4 (4), p.323-329
Hauptverfasser: Crespi, F., Keane, P.E.
Format: Artikel
Sprache:eng
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Zusammenfassung:The effects of diazepam (10 mg/kg i.p.) and the central benzodiazepine receptor antagonist, Ro 15–1788 (30 mg/kg i.p.), on extracellular ascorbate, 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) were examined using differential pulse voltammetry in anaesthetized and freely moving rats. In anaesthetized animals, diazepam did not significantly alter the heights of peak 1 (ascorbate) or peak 3 (5-HIAA), but significantly reduced that of peak 2 (DOPAC). In freely moving rats, diazepam greatly reduced the heights of all 3 peaks. Ro 15–1788, injected 2 h after diazepam, reversed the effect of diazepam on peak 3, but not on peaks 1 and 2.
ISSN:0168-0102
1872-8111
DOI:10.1016/0168-0102(87)90049-6