Influence of lung stiffness on rapidly adapting receptors in rabbits and cats

We examined the response of rapidly adapting receptors (RARs) to changes in dynamic lung compliance (C dyn), recording vagal impulses in open-chest rabbits and cats with lungs ventilated at constant f and v t, and a positive end-expiratory pressure (PEEP) of 3–4 cm H 2O. After hyperinflation to prod...

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Veröffentlicht in:	Respiration physiology 1987-05, Vol.68 (2), p.161-176
Hauptverfasser:	Yu, J., Coleridge, J.C.G., Coleridge, H.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - physiology Air breathing Animals Atropine - pharmacology Biological and medical sciences Cats Control of breathing Dynamic lung compliance Elasticity Fundamental and applied biological sciences. Psychology Gasp reflex Inflation rate Irritant receptors Lung - drug effects Lung - physiology Lung elastance Mechanoreceptors - physiology Positive-Pressure Respiration Pressure Pulmonary Stretch Receptors - drug effects Pulmonary Stretch Receptors - physiology Rabbits Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Space life sciences Tidal Volume Vagus Nerve - physiology Vertebrates: respiratory system
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Zusammenfassung:	We examined the response of rapidly adapting receptors (RARs) to changes in dynamic lung compliance (C dyn), recording vagal impulses in open-chest rabbits and cats with lungs ventilated at constant f and v t, and a positive end-expiratory pressure (PEEP) of 3–4 cm H 2O. After hyperinflation to produce maximal c dyn, most RARs fired irregularly and sparsely (< 1 impulse · sec 1). Reducing c dyn in steps by briefly removing PEEP progressively stimulated RARs during inflation, activity increasing sevenfold when c dyn was reduced by 40% ( P
ISSN:	0034-5687
DOI:	10.1016/S0034-5687(87)80003-8