Decreased muscarinic receptor binding in cerebral cortex and hippocampus in alzheimer's disease

Decreased muscarinic receptor binding in cerebral cortex and hippocampus in alzheimer's disease

Muscarinic (cholinergic) receptor binding sites (MRB) were studied by determining the 3H-QNB binding in four cortical areas and hippocampus of 20 histologically confirmed Alzheimer patients and comparing these with corresponding controls. Alzheimer patients dying at younger age (≤80) with profound d...

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Veröffentlicht in:Life sciences (1973) 1987-07, Vol.41 (4), p.453-461
Hauptverfasser: Reinikainen, K.J., Riekkinen, P.J., Halonen, T., Laakso, M.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Alzheimer Disease - metabolism
Biological and medical sciences
Cerebral Cortex - metabolism
Choline O-Acetyltransferase - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Hippocampus - metabolism
Humans
Medical sciences
Neurology
Quinuclidinyl Benzilate - metabolism
Receptors, Muscarinic - metabolism
Tissue Distribution
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Zusammenfassung:Muscarinic (cholinergic) receptor binding sites (MRB) were studied by determining the 3H-QNB binding in four cortical areas and hippocampus of 20 histologically confirmed Alzheimer patients and comparing these with corresponding controls. Alzheimer patients dying at younger age (≤80) with profound decrease in cholineacetyltransferase activity (by 61–85 %) and without any, possibly MRB modifying, drug treatment showed 30 % decrease in MRB in the frontal cortex (p
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(87)90221-9