Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants
The use of a concentrate containing milk immunoglobulins prepared from rotavirus-hyperimmunized cows (neutralization titer, 1:6,000 for a 10% solution) to treat infants hospitalized for acute rotavirus gastroenteritis resulted in a significant (P = .008) reduction in the duration of excretion of vir...
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| Veröffentlicht in: | The Journal of infectious diseases 1987-07, Vol.156 (1), p.158-166 |
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| container_title | The Journal of infectious diseases |
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| creator | Hilpert, Helmut Briissow, Harald Mietens, Carl Sidoti, Josette Lerner, Lothar Werchau, Hermann |
| description | The use of a concentrate containing milk immunoglobulins prepared from rotavirus-hyperimmunized cows (neutralization titer, 1:6,000 for a 10% solution) to treat infants hospitalized for acute rotavirus gastroenteritis resulted in a significant (P = .008) reduction in the duration of excretion of virus. Stool samples from treated infants showed the presence of bovine milk immunoglobulins in 47% of cases and of neutralizing activity in 43% (mean neutralization titer, 1:48); stool samples from control infants showed neutralizing activities in only 3% of cases (neutralization titers, |
| doi_str_mv | 10.1093/infdis/156.1.158 |
| format | Article |
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Stool samples from treated infants showed the presence of bovine milk immunoglobulins in 47% of cases and of neutralizing activity in 43% (mean neutralization titer, 1:48); stool samples from control infants showed neutralizing activities in only 3% of cases (neutralization titers, <1:20). Immunoelectrophoresis of stool extracts revealed fragment A, a bovine analogue of F(ab′)2 or Fab, as the major product of in vitro and in vivo digestion of the immunoglobulins. Cessation of excretion of virus correlated with the appearance of neutralizing activities in 19 of 25 infants. Only concentrate-treated infants with high neutralizing activity in stools showed a statistically significant reduction in duration of excretion of virus; this duration in concentrate-treated infants with low neutralizing activity was comparable with controls.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/156.1.158</identifier><identifier>PMID: 3110303</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Antibodies ; Antibodies, Viral - analysis ; Antibodies, Viral - immunology ; Biological and medical sciences ; Cattle ; Child, Preschool ; Children ; Diarrhea ; Enzyme-Linked Immunosorbent Assay ; Excretion ; Feces - microbiology ; Female ; Gastroenteritis ; Gastroenteritis - therapy ; Human viral diseases ; Humans ; Immunization, Passive ; Immunoglobulins ; Immunoglobulins - analysis ; Infant ; Infant, Newborn ; Infants ; Infectious diseases ; Male ; Medical sciences ; Milk - immunology ; Neutralization Tests ; Original Articles ; Pepsin A - pharmacology ; Rotavirus ; Rotavirus Infections - therapy ; Ungulates ; Viral diseases ; Viral diseases of the digestive system ; Viruses</subject><ispartof>The Journal of infectious diseases, 1987-07, Vol.156 (1), p.158-166</ispartof><rights>Copyright 1987 The University of Chicago</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-3211c04475b44d1bdda94f3ce943452ac5d2d6086474c09d6ec03442e70b01993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30136519$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30136519$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7595066$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3110303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hilpert, Helmut</creatorcontrib><creatorcontrib>Briissow, Harald</creatorcontrib><creatorcontrib>Mietens, Carl</creatorcontrib><creatorcontrib>Sidoti, Josette</creatorcontrib><creatorcontrib>Lerner, Lothar</creatorcontrib><creatorcontrib>Werchau, Hermann</creatorcontrib><title>Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The use of a concentrate containing milk immunoglobulins prepared from rotavirus-hyperimmunized cows (neutralization titer, 1:6,000 for a 10% solution) to treat infants hospitalized for acute rotavirus gastroenteritis resulted in a significant (P = .008) reduction in the duration of excretion of virus. Stool samples from treated infants showed the presence of bovine milk immunoglobulins in 47% of cases and of neutralizing activity in 43% (mean neutralization titer, 1:48); stool samples from control infants showed neutralizing activities in only 3% of cases (neutralization titers, <1:20). Immunoelectrophoresis of stool extracts revealed fragment A, a bovine analogue of F(ab′)2 or Fab, as the major product of in vitro and in vivo digestion of the immunoglobulins. Cessation of excretion of virus correlated with the appearance of neutralizing activities in 19 of 25 infants. Only concentrate-treated infants with high neutralizing activity in stools showed a statistically significant reduction in duration of excretion of virus; this duration in concentrate-treated infants with low neutralizing activity was comparable with controls.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibodies, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Diarrhea</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Excretion</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - therapy</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization, Passive</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins - analysis</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Milk - immunology</subject><subject>Neutralization Tests</subject><subject>Original Articles</subject><subject>Pepsin A - pharmacology</subject><subject>Rotavirus</subject><subject>Rotavirus Infections - therapy</subject><subject>Ungulates</subject><subject>Viral diseases</subject><subject>Viral diseases of the digestive system</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9PFDEUxxujwRW9ezHpwXib5b3pr-0RVwUiRGMgMVyaTqdjCrMttF0i_z2z2QW8eWn7-v2-T177JeQ9whxBs4MQhz6UAxRyjnMUixdkhoKpRkpkL8kMoG0bXGj9mrwp5QoAOJNqj-wxRGDAZmR1UTxNA_2c7kL09CyM13SZovOxZlv95lxtiCH-oYexhi7197Qm-itVexfyumyK8-xt_efqyJaa00TwOdRQaIj0JA421vKWvBrsWPy73b5PLr59PV8eN6c_jk6Wh6eNE21bG9YiOuBciY7zHru-t5oPzHnNGRetdaJvewkLyRV3oHvpHTDOW6-gA9Sa7ZNPW-5NTrdrX6pZheL8ONro07oYpYRutYb_GpErqQFwMsLW6HIqJfvB3OSwsvneIJhNFGYbhZmiMDiti6nlw4697la-f2rY_f2kf9zptjg7DtlGNwEebdOIAqR8xlyVmvIzZRpKCty8tdnqoVT_90m3-dpIxZQwx78vzRn__hOFvjRf2AM9k6t3</recordid><startdate>19870701</startdate><enddate>19870701</enddate><creator>Hilpert, Helmut</creator><creator>Briissow, Harald</creator><creator>Mietens, Carl</creator><creator>Sidoti, Josette</creator><creator>Lerner, Lothar</creator><creator>Werchau, Hermann</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19870701</creationdate><title>Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants</title><author>Hilpert, Helmut ; Briissow, Harald ; Mietens, Carl ; Sidoti, Josette ; Lerner, Lothar ; Werchau, Hermann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-3211c04475b44d1bdda94f3ce943452ac5d2d6086474c09d6ec03442e70b01993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - analysis</topic><topic>Antibodies, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Diarrhea</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Excretion</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastroenteritis</topic><topic>Gastroenteritis - therapy</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunization, Passive</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins - analysis</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Milk - immunology</topic><topic>Neutralization Tests</topic><topic>Original Articles</topic><topic>Pepsin A - pharmacology</topic><topic>Rotavirus</topic><topic>Rotavirus Infections - therapy</topic><topic>Ungulates</topic><topic>Viral diseases</topic><topic>Viral diseases of the digestive system</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hilpert, Helmut</creatorcontrib><creatorcontrib>Briissow, Harald</creatorcontrib><creatorcontrib>Mietens, Carl</creatorcontrib><creatorcontrib>Sidoti, Josette</creatorcontrib><creatorcontrib>Lerner, Lothar</creatorcontrib><creatorcontrib>Werchau, Hermann</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hilpert, Helmut</au><au>Briissow, Harald</au><au>Mietens, Carl</au><au>Sidoti, Josette</au><au>Lerner, Lothar</au><au>Werchau, Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1987-07-01</date><risdate>1987</risdate><volume>156</volume><issue>1</issue><spage>158</spage><epage>166</epage><pages>158-166</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The use of a concentrate containing milk immunoglobulins prepared from rotavirus-hyperimmunized cows (neutralization titer, 1:6,000 for a 10% solution) to treat infants hospitalized for acute rotavirus gastroenteritis resulted in a significant (P = .008) reduction in the duration of excretion of virus. Stool samples from treated infants showed the presence of bovine milk immunoglobulins in 47% of cases and of neutralizing activity in 43% (mean neutralization titer, 1:48); stool samples from control infants showed neutralizing activities in only 3% of cases (neutralization titers, <1:20). Immunoelectrophoresis of stool extracts revealed fragment A, a bovine analogue of F(ab′)2 or Fab, as the major product of in vitro and in vivo digestion of the immunoglobulins. Cessation of excretion of virus correlated with the appearance of neutralizing activities in 19 of 25 infants. 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| ispartof | The Journal of infectious diseases, 1987-07, Vol.156 (1), p.158-166 |
| issn | 0022-1899 1537-6613 |
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| subjects | Animals Antibodies Antibodies, Viral - analysis Antibodies, Viral - immunology Biological and medical sciences Cattle Child, Preschool Children Diarrhea Enzyme-Linked Immunosorbent Assay Excretion Feces - microbiology Female Gastroenteritis Gastroenteritis - therapy Human viral diseases Humans Immunization, Passive Immunoglobulins Immunoglobulins - analysis Infant Infant, Newborn Infants Infectious diseases Male Medical sciences Milk - immunology Neutralization Tests Original Articles Pepsin A - pharmacology Rotavirus Rotavirus Infections - therapy Ungulates Viral diseases Viral diseases of the digestive system Viruses |
| title | Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants |
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